ArticleJournal of arrhythmia2025
Radiofrequency or cryoablation or medical therapy for paroxysmal atrial fibrillation: An indirect comparison of effectiveness.
Article in Journal of arrhythmia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Radiofrequency or cryoablation or medical therapy for paroxysmal atrial fibrillation: An indirect comparison of effectiveness.Journal of arrhythmia · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Paroxysmal atrial fibrillation (PAF) is commonly treated with pharmacological therapies, but these may be insufficient for symptom control. Radiofrequency and cryoballoon ablation have emerged as alternative strategies. This study aimed to compare the efficacy of cryoballoon ablation, radiofrequency ablation, and anti-arrhythmic drugs as initial therapies for symptomatic PAF based on randomized trial data. Methods: Data were extracted from randomized trials, and individual patient data were reconstructed from Kaplan-Meier curves using artificial intelligence techniques. Time-to-event analysis was performed to evaluate arrhythmia recurrence, with hazard ratios (HRs) as the primary measure of efficacy. A heterogeneity analysis was conducted to assess variability between studies. Results: Five randomized trials were included in the analysis. Significant between-trial heterogeneity was observed. Both cryoballoon ablation (HR 0.48; 95% CI: 0.36-0.63; Conclusions: Cryoballoon and radiofrequency ablation are more effective than anti-arrhythmic drugs for initial therapy in symptomatic PAF. These findings support the use of ablation techniques as preferred interventions in this patient population.
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Registered trials
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