Evidence map›Paper›PMID 40171127›Full record

ArticleChem & bio engineering2025

Two-Step Synthesis of a Dolutegravir Intermediate DTG-6 in a Microfluidized Bed Cascade System: Route Design and Kinetic Study.

Xiao Xue, Chengmin Xie, Guozhi Qian, Minjing Shang, Min Qiu, Rongkun Jiang, Mohsin Pasha, Zihao Zhong, Zhijun Wang, Shu Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chem & bio engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiao XueSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.ORCID https://orcid.org/0000-0001-5788-2460
Chengmin XieSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Guozhi QianSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Minjing ShangSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Min QiuSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Rongkun JiangState Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
Mohsin PashaSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Zihao ZhongSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Zhijun WangShanghai Desano Pharmaceuticals Co., Ltd., Shanghai 201203, People's Republic of China.
Shu LiuShanghai Desano Pharmaceuticals Co., Ltd., Shanghai 201203, People's Republic of China.
Hua ZhangShanghai Desano Pharmaceuticals Co., Ltd., Shanghai 201203, People's Republic of China.
Yuanhai SuSchool of Chemistry and Chemical Engineering, Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.ORCID https://orcid.org/0000-0002-0718-301X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the existing two-step method for the preparation of DTG-6 (i.e., an important intermediate of the anti-HIV drug Dolutegravir (DTG)), a strong base is required to neutralize the homogeneous strong acid catalyst of the first step to make the reaction solution weakly acidic for the DTG-5 cyclization in the second step. The DTG-6 yield in the two-step synthesis is affected by the reaction of the strong base with the carboxyl group on the generated intermediate DTG-5. In this article, a solid acid catalyst, titanium cation-exchanged montmorillonite (Ti

Identifiers

PMID40171127
PMCPMC11955854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.