Evidence map›Paper›PMID 40171024›Full record

ArticleChemical science2025

Histidine-rich enantiomeric peptide coacervates enhance antigen sequestration and presentation to T cells.

Ushasi Pramanik, Anirban Das, Elise M Brown, Heather L Struckman, Huihao Wang, Samuel Stealey, Macy L Sprunger, Abdul Wasim, Jonathan Fascetti, Jagannath Mondal and 4 more

Abstract read
In one paragraph

Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Substituent-Based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ushasi PramanikDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis St. Louis MO 63130 USA srudra22@wustl.edu.ORCID https://orcid.org/0000-0002-2991-3685
Anirban DasDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis St. Louis MO 63130 USA srudra22@wustl.edu.
Elise M BrownDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis St. Louis MO 63130 USA srudra22@wustl.edu.ORCID https://orcid.org/0000-0003-4242-914X
Heather L StruckmanDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis St. Louis MO 63130 USA srudra22@wustl.edu.
Huihao WangDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis St. Louis MO 63130 USA srudra22@wustl.edu.
Samuel StealeyDepartment of Biomedical Engineering, Saint Louis University St. Louis MO 63103 USA.ORCID https://orcid.org/0000-0001-6355-4551
Macy L SprungerDepartment of Chemistry, Washington University in St. Louis St. Louis MO 63130 USA.
Abdul WasimTata Institute of Fundamental Research Hyderabad Hyderabad 500046 India.
Jonathan FascettiDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis St. Louis MO 63130 USA srudra22@wustl.edu.
Jagannath MondalTata Institute of Fundamental Research Hyderabad Hyderabad 500046 India.ORCID https://orcid.org/0000-0003-1090-5199
Jonathan R SilvaDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis St. Louis MO 63130 USA srudra22@wustl.edu.
Silviya P ZustiakDepartment of Biomedical Engineering, Saint Louis University St. Louis MO 63103 USA.ORCID https://orcid.org/0000-0002-7648-8351
Meredith E JackrelDepartment of Chemistry, Washington University in St. Louis St. Louis MO 63130 USA.
Jai S RudraDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis St. Louis MO 63130 USA srudra22@wustl.edu.ORCID https://orcid.org/0000-0002-7837-4980

Funding

Mechanisms of Nanomaterials-based Combination AdjuvantsR01AI168918 · NIAID · WASHINGTON UNIVERSITY · PI Jai Rudra · 2023 to 2026
$2.0M
Elucidating the roles of protein disaggregases and developing enhanced diaggregases to counter diverse protein-misfolding disordersR35GM153303 · NIGMS · WASHINGTON UNIVERSITY · PI Meredith E. Jackrel · 2024 to 2026
$1.4M
NIAID NIH HHS R01 AI168918NIGMS NIH HHS R35 GM153303
6 · The paper itself

Abstract

Peptides and peptidomimetics that self-assemble through LLPS have recently emerged as vital building blocks for creating functional biomaterials, thanks to their unique physicochemical properties and dynamic nature. One of life's most distinctive features is its selectivity for chiral molecules. To date, coacervates comprised of d-amino acids have not been reported. Here, we demonstrate that histidine-rich repeats of (GHGXY)

Identifiers

PMID40171024
PMCPMC11955804

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.