Evidence map›Paper›PMID 40170849›Full record

ArticleFrontiers in immunology2025

TPL2 kinase activity is required for

Denise L Fahey, Niki Patel, Wendy T Watford

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Denise L FaheyDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Niki PatelCollege of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Wendy T WatfordDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
J: NRSA Training CoreTL1TR002382 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Vasiliki Michopoulos · 2017 to 2026
$8.5M
Regulation of mucosal immunity to respiratory viruses by Tpl2R21AI147003 · NIAID · UNIVERSITY OF GEORGIA · PI WATFORD, WENDY T · 2019 to 2020
$415k
NCATS NIH HHS TL1 TR002382NCATS NIH HHS UL1 TR002378NIAID NIH HHS R21 AI147003
6 · The paper itself

Abstract

The NLRP3 inflammasome complex is an important mechanism for regulating the release of pro-inflammatory cytokines, IL-1β and IL-18, in response to harmful pathogens. Overproduction of pro-inflammatory cytokines has been linked to cryopyrin-associated periodic syndrome, arthritis, and other inflammatory conditions. It has been previously shown that tumor progression locus 2, a serine-threonine kinase, promotes IL-1β synthesis in response to LPS stimulation; however, whether TPL2 kinase activity is required during inflammasome priming to promote

Indexed as

InflammasomesInterleukin-1betaMAP Kinase Kinase KinasesNLR Family, Pyrin Domain-Containing 3 ProteinProto-Oncogene ProteinsAnimalsCaspase 1LipopolysaccharidesMacrophagesMiceMice, Inbred C57BLMice, KnockoutTranscription, GeneticCaspase 1IL1B protein, mouseInflammasomesInterleukin-1betaLipopolysaccharidesMap3k8 protein, mouseMAP Kinase Kinase KinasesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseProto-Oncogene ProteinsIL-1binterferonsNLRP3 inflammasomeTPL2Tpl2 kinasetype I IFN

Identifiers

PMID40170849
PMCPMC11958189

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.