Evidence map›Paper›PMID 40170767›Full record

ArticleClinics in orthopedic surgery2025

A Comparative Study on the Effects of Repeated Subacromial Injections of Parecoxib and Triamcinolone in a Rat Model of Normal Rotator Cuff.

Jong Pil Yoon, Dong Hyun Kim, Sung-Jin Park, Yoon Seong Choi, Hyun Joo Lee, Seok Won Chung, Kang-San Lee, Jeoung Wook Lee

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinics in orthopedic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jong Pil YoonDepartment of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0000-0001-6446-6254
Dong Hyun KimDepartment of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0000-0001-9078-5953
Sung-Jin ParkDepartment of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0009-0008-6869-0788
Yoon Seong ChoiDepartment of Carbon Hybrid Fiber Science, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0009-0006-1483-0023
Hyun Joo LeeDepartment of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0000-0003-2837-3434
Seok Won ChungDepartment of Orthopedic Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-8221-9289
Kang-San LeeDepartment of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0000-0001-7932-0426
Jeoung Wook LeeDepartment of Orthopedic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0009-0003-1216-263X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Backgroud: This study aimed to investigate changes after repeated subacromial drug injections in a rat model of normal rotator cuff. Methods: Thirty-nine male Sprague-Dawley rats were divided into groups 1 (no injection, n = 3), 2 (parecoxib, n = 18; 6 subgroups, n = 3 each; 0.5 mg/kg), and 3 (triamcinolone, n = 18; 6 subgroups, n = 3 each; 0.3 mg/kg). Groups 2 and 3 received subacromial injections 1-6 times once weekly for 6 weeks. The supraspinatus and infraspinatus tendons and muscles were used for biomechanical and histological evaluation. The subacromial bursa was used to analyze the prostaglandin E2 (PEG2) level. Results: In the biomechanical test, load-to-failure and ultimate stress decreased in groups 2 and 3 with repeated injections and the values were significantly lower in group 3 than in group 1 only at the sixth injection ( Conclusions: In the rat model of normal rotator cuff, repeated local injections of the cyclooxygenase-2 inhibitor showed fewer negative effects on the biomechanical and histological properties of the normal tendon than triamcinolone.

Indexed as

Cyclooxygenase 2 InhibitorsIsoxazolesRotator CuffTriamcinoloneAnimalsBiomechanical PhenomenaDinoprostoneDisease Models, AnimalInjections, Intra-ArticularMaleRatsRats, Sprague-DawleyCyclooxygenase 2 InhibitorsDinoprostoneIsoxazolesparecoxibTriamcinoloneCyclooxygenase 2 inhibitorsInjectionsRotator cuffTriamcinolone

Identifiers

PMID40170767
PMCPMC11957830

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.