Evidence map›Paper›PMID 40170570›Full record

ArticleHuman vaccines & immunotherapeutics2025

Excretion and clearance of Sabin-like type 3 poliovirus in a child diagnosed with severe combined immunodeficiency.

Ning Yao, Yang Liu, Zhi-Yong Zhang, Min Tian, Wu-Juan Xie, Hua Zhao, Hong Yang, Lance E Rodewald, Ning Wen, Zun-Dong Yin and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ning YaoDepartment of Expanded Immunization Program, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China.
Yang LiuDepartment of Expanded Immunization Program, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China.
Zhi-Yong ZhangDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Min TianDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Wu-Juan XieDepartment of Expanded Immunization Program, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China.
Hua ZhaoDepartment of Expanded Immunization Program, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China.
Hong YangNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, China.
Lance E RodewaldNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, China.
Ning WenNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, China.
Zun-Dong YinNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, China.
Fu-Zhen WangNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, China.
Qing WangDepartment of Expanded Immunization Program, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China.
Jia-Wei XuDepartment of Expanded Immunization Program, Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China.ORCID 0000-0003-1492-7571

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children with primary immunodeficiency disorder (PID) are at higher risk of developing vaccine-associated paralytic poliomyelitis (VAPP) or vaccine-derived polioviruses (VDPV) infection when inadvertently expose to poliovirus vaccine, oral (OPV). A pilot study was initiated to describe the epidemiology of immunodeficiency-associated VDPV (iVDPV) and to estimate the risk of iVDPV shedding among individuals with PID. Children under 18 years of age newly diagnosed with PID were recruited for investigation and tested for poliovirus excretion. Children with poliovirus-positive stool samples had regular follow-up testing for poliovirus excretion and determination of clinical prognosis. A patient with severe combined immunodeficiency (SCID) with compound heterozygous mutations in the

Indexed as

PoliomyelitisPoliovirusSevere Combined ImmunodeficiencyVirus SheddingChildChild, PreschoolFecesFemaleHematopoietic Stem Cell TransplantationHomeodomain ProteinsHumansInfantMalePilot ProjectsPoliovirus Vaccine, OralHomeodomain ProteinsPoliovirus Vaccine, OralRAG-1 proteinchildrenhematopoietic stem-cell transplantationpoliovirus type 3poliovirus vaccine, oralPrimary immunodeficiency disorder

Identifiers

PMID40170570
PMCPMC11970734

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.