ArticleBrain and behavior2025
Suicidal Ideation in Patients With Multiple Sclerosis and Its Association With Clinical and Demographic Characteristics.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Suicide in neurodegenerative diseases: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- The association between depressive symptoms and sleep quality in patients with multiple sclerosis: a systematic review and meta-analysis.BMC neurology · 2026Pooled it
- Global Prevalence and Risk Factors of Suicidal Ideation in Multiple Sclerosis: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Depression, trauma, stressful life events and childhood infections in patients with multiple sclerosis in the Polish population - a case-control study.Postepy psychiatrii neurologii · 2026Article
- Suicidal ideation and interrelated psychiatric disturbances in rheumatoid arthritis: Evidence from a Vietnamese cohort.PloS one · 2026Article
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Authors and funding
9 authors.
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Abstract
backgroundChronic neurological diseases, such as multiple sclerosis (MS) are important risk factors for some psychological disorders, such as depression and consequently suicidal behavior. As suicidal ideation (SI) is one of the important factors in predicting suicide attempts and suicide deaths, the recognition of factors related to the occurrence of SI in patients with MS has high value.
objectiveThis study aims to assess the association between sociodemographic, psychological, and disease characteristics with SI in patients with MS.
methodsA sample of 400 subjects with MS was selected from a referral outpatient MS clinic in Tehran, Iran (2024). Participants completed a personal information questionnaire, the patient health questionnaire-9 (PHQ-9), the hospital anxiety and depression scale (HADS), and the beck scale for suicidal ideation (BSSI). Logistic regression models (univariate and multivariate) were conducted to determine the association between each variable and SI using odds ratio (OR) and 95% confidence interval (CI). Finally, the correlation between depression, anxiety, and the SI scale was measured by bivariate Pearson correlation analyses.
resultsThe sample consisted of 77% women, and the mean age was 36.91 years. Among them, 149 (37.2%) of cases were identified with suicidal ideation at some period in life. Findings in the multivariate regression model represented that an increase in age had a significant protective effect on SI (adjusted OR [AOR] 0.95, 95% CI 0.92 to 0.98, p = 0.003). Moreover, the history of previous suicide attempts doubled the odds of SI (AOR 2.18, 95% CI 1.05 to 4.54, P = 0.038). Finally, both depression score (measured by PHQ-9) and anxiety score (measured by HADS) had significant associations with SI.
conclusionPeople with MS are highly prone to suicidal thoughts and even suicide attempts; this should not be ignored in routine clinical visits due to other physical complaints. They need to be discussed with patients, and effective psychiatric interventions should be applied to reduce the risks.
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