Evidence map›Paper›PMID 40170524›Full record

ArticlePhysiological reports2025

Subtherapeutic lithium supplementation causes physiological eccentric cardiac hypertrophy in young-adult wild-type male mice.

Sophie I Hamstra, Mia S Geromella, Peter Tiidus, Panagiota Klentrou, Rebecca E K MacPherson, Val A Fajardo

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sophie I HamstraDepartment of Kinesiology, Brock University, St. Catharines, Ontario, Canada.ORCID 0000-0001-8418-449X
Mia S GeromellaDepartment of Kinesiology, Brock University, St. Catharines, Ontario, Canada.
Peter TiidusDepartment of Kinesiology, Brock University, St. Catharines, Ontario, Canada.
Panagiota KlentrouDepartment of Kinesiology, Brock University, St. Catharines, Ontario, Canada.
Rebecca E K MacPhersonDepartment of Health Sciences, Brock University, St. Catharines, Ontario, Canada.ORCID 0000-0002-1577-2658
Val A FajardoDepartment of Kinesiology, Brock University, St. Catharines, Ontario, Canada.ORCID 0000-0003-4500-3347

Funding

Canada Research Chair Tier II CRC-2019-00412Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2019-05833
6 · The paper itself

Abstract

Six weeks of low-dose lithium (Li) supplementation has been shown to improve the activity of cardiac sarco(endo)plasmic reticulum calcium (Ca

Indexed as

CardiomegalyLithiumAnimalsCalciumCalcium-Binding ProteinsDietary SupplementsGlycogen Synthase Kinase 3 betaMaleMiceMice, Inbred C57BLMyocardial ContractionPhospholambanSarcoplasmic Reticulum Calcium-Transporting ATPasesVentricular RemodelingAtp2a2 protein, mouseCalciumCalcium-Binding ProteinsGlycogen Synthase Kinase 3 betaLithiumPhospholambanSarcoplasmic Reticulum Calcium-Transporting ATPasescardiac functioneccentric hypertrophyGSK3lithiumSERCA

Identifiers

PMID40170524
PMCPMC11962211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.