ArticleBrain and behavior2025
Increased Brain Age Among Psychiatrically Healthy Adults Exposed to Childhood Trauma.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- The moderating role of psychological resilience on brain aging and PTSD in a community sample of South African women.Neuroscience · 2026Article
- Structural brain alterations associated with brain age may link to social dysfunction in male adults with autism spectrum disorder.Frontiers in neuroscience · 2026Article
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5 authors.
Funding
Abstract
backgroundAdults with childhood trauma exposure may exhibit brain changes typically associated with aging and neurodegeneration (e.g., reduced tissue volume or integrity) to a greater degree than their unexposed counterparts, suggesting accelerated brain aging. Machine learning methods that predict a person's age based on their magnetic resonance imaging (MRI) brain scan may be useful for investigating aberrant brain aging following childhood trauma exposure. Emerging evidence indicates altered brain aging in adolescents with childhood trauma exposure; however, this association has not been examined in healthy adults.
methodsWe investigated the associations between childhood trauma exposure, including abuse and neglect, and brain-predicted age in psychiatrically healthy adults. "Brain age" predictions were generated from T1-weighted structural MRI scans using a pre-trained machine learning pipeline, namely brainageR. The differences between brain-predicted age and chronological age were calculated and associations with childhood trauma questionnaire scores were investigated using linear regression.
resultsThe final sample (n = 153; mean age 46 ± 16 years, 70% female) included 69 adults with childhood trauma exposure and 84 unexposed adults. Childhood sexual abuse was associated with an average increased brain age of 3.2 years, adjusting for chronological age and age-squared, sex, and scanner site; however, this finding did not survive correction for multiple comparisons.
conclusionsTo our knowledge, this study represents the first published investigation of brain age in adults with childhood trauma using a machine-learning-based prediction model. Our findings suggest a link between childhood trauma exposure, specifically sexual abuse, and accelerated brain aging in adulthood, but this association should be replicated in future work. Accentuated brain aging in adulthood may increase the risk of age-related cognitive and neurodegenerative decline and associated disorders later in life.
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