Evidence map›Paper›PMID 40170513›Full record

ArticleMolecular carcinogenesis2025

Association of SIRT6 Expression With Risk of Pneumonitis Induced by Radiotherapy in Cancer Patients.

Fengyuan Yu, Zheng Gong, Yuan Li, Danial F Naseem, Chen Li, Miaowei Wen, Bingying Zhao, Zhezhe Xu, Shanshan Zhang, Rukun Zang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular carcinogenesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fengyuan YuDepartment of Radiotherapy, Qingdao University, Qingdao, China.
Zheng GongDepartment of Radiotherapy, Qingdao University, Qingdao, China.
Yuan LiDepartment of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, PR China.ORCID 0000-0002-5969-708X
Danial F NaseemDepartment of Head and Neck Surgery, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-1247-6140
Chen LiDepartment of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Miaowei WenDepartment of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Bingying ZhaoDepartment of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Zhezhe XuDepartment of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Shanshan ZhangDepartment of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Rukun ZangDepartment of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Ailu WuDepartment of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Qingxin HanDepartment of Radiotherapy, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Shuhui WuDepartment of Otorhinolaryngology, Baoshan Hospital Affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
Hongwei LiDepartment of Radiotherapy, Qingdao University, Qingdao, China.
Yipeng SongDepartment of Radiotherapy, Qingdao University, Qingdao, China.

Funding

This research is supported by the Natural Science Foundation of Shandong Province (ZR2022MH129 and ZR2022LSW012) and Yantai Yuhuangding Hospital Research and Development Fund (2022-07).
6 · The paper itself

Abstract

Thoracic tumours represent a significant proportion of malignant cancers. While radiotherapy (RT) improves prognosis, it can also lead to side effects such as radiation-induced pneumonitis (RP). Since SIRT6 is involved in DNA repair, energy metabolism and inflammation, this study aims to investigate the expression of SIRT6 in lymphocytes as a potential biomarker and therapeutic target for RP. This study included 170 patients diagnosed with thoracic tumours, all of whom underwent thoracic RT. RP was evaluated and classified as severe RP (SRP) and lower as non-severe RP (NSRP). Analyses were performed using SPSS version 26.0 and the R. Among 170 patients in this study, 124 developed NSRP, and 46 experienced SRP. The univariate analysis showed that SIRT6 expression (cOR, 0.33, 95%CI, 0.18-0.97 before RT and 0.31, 0.19-0.98 after RT), clinical factors, dosimetric parameters and haematological/serological parameters were associated with SRP before and after RT. Our multivariable logistic regression showed that SIRT6 expression was significantly associated with risk of SRP before (aOR, 0.32, 95%CI, 0.15-0.96) and after RT (aOR, 0.32, 95%CI, 0.18-0.99) after adjustment with other confounders. Moreover, the receiver operating characteristic curve analysis revealed that the combined multivariable model exhibited superior predictive capability compared to any single predictor (overall AUC, 0.93, 95%CI, 0.90-0.97 before RT and AUC, 0.91, 95%CI, 0.87-0.96 after RT). The expression of SIRT6 alone or in combination with other risk factors was associated with an increased risk of SRP, suggesting a novel approach for the prevention and treatment of radiation pneumonitis in clinical practice.

Indexed as

Radiation PneumonitisRadiotherapySirtuinsThoracic NeoplasmsAdultAgedFemaleHumansLymphocytesMaleMiddle AgedPrognosisRisk FactorsROC CurveSIRT6 protein, humanSirtuinslymphocyteradiation pneumonitisradiotherapySIRT6thoracic tumours

Identifiers

PMID40170513
PMCPMC12074565

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.