Evidence map›Paper›PMID 40170237›Full record

ArticleThe journal of trauma and acute care surgery2025

Is Resuscitative Endovascular Balloon Occlusion of the Aorta contraindicated in the elderly? An analysis of the American Association for the Surgery of Trauma Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery registry.

Reynold Henry, Daniel Lammers, Ashley Clegg, Lindsey Loss, Anna White, Christopher D Barrett, Megan Brenner, Joseph J Dubose, Kazuhide Matsushima, Kenji Inaba and 1 more

Abstract read
In one paragraph

Article in The journal of trauma and acute care surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Reynold HenryFrom the Division of Acute Care Surgery (R.H., K.M., K.I.), University of Southern California, Los Angeles, California; Division of Acute Care Surgery (R.H., A.C., A.W., C.D.B.), University of Nebraska Medical Center, Omaha, Nebraska; Division of Division of Trauma, Critical Care and Acute Care Surgery (R.H, L.L), Oregon Health & Science University, Portland, Oregon; Division of Acute Care Surgery (D.L.), University of North Carolina; Chapel Hill, North Carolina; Division of Trauma and Acute Care Surgery (M.B.), University of California, Los Angeles, Los Angeles, California; and Division of Acute Care Surgery (J.J.D.), University of Texas, Austin, Texas.ORCID 0000-0002-2662-5485
Daniel Lammers
Ashley Clegg
Lindsey Loss
Anna White
Christopher D Barrett
Megan Brenner
Joseph J Dubose
Kazuhide Matsushima
Kenji Inaba
AORTA Study Group

Funding

Using Patient-Reported Outcomes, Inflammatory Profiles, and Cardiovascular Phenogroups to Expand the Definition of Heart Failure with Preserved Ejection FractionP20GM152326 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Jason Rhede Cook · 2024 to 2026
$10.3M
Mechanisms of Complement Activation in Traumatic InjuryK08HL171936 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Christopher David Barrett · 2024 to 2026
$500k
NHLBI NIH HHS K08 HL171936NIGMS NIH HHS P20 GM152326
6 · The paper itself

Abstract

introductionResuscitative endovascular balloon occlusion of the aorta (REBOA) has emerged as a critical tool in trauma management, particularly for elderly patients. However, its application in this population is often debated because of concerns over potential complications. This study evaluates the outcomes of REBOA compared with resuscitative thoracotomy (RT) in trauma patients 65 years or older with indications for aortic occlusion.

methodsA retrospective cohort analysis was conducted using the Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery registry (2013-2024), including trauma patients presented pulseless or sustained cardiac arrest in the trauma bay during evaluation. Patients were divided into REBOA and RT groups based on the aortic occlusion method selected at physician discretion. Variables analyzed included demographics, injury severity, hemorrhage control procedures, transfusion needs, and clinical outcomes. Multivariate analyses accounted for confounders, such as penetrating injuries, Injury Severity Score of >15, systolic blood pressure of <90 mm Hg, heart rate of >100 beats per minute, Glasgow Coma Scale score of <9, provider type, and the need for hemorrhage control procedures.

resultsThe study included 360 patients (RT, 162; REBOA, 198). Survival to hemorrhage control was significantly higher in the REBOA group (75.8% vs. 49.4%, p < 0.001), and overall, in-hospital mortality was lower (74.6% vs. 97.5%, p < 0.001). Major complications were similar between groups, but minor complications occurred more frequently in the REBOA cohort (34.7% vs. 6.3%, p < 0.001). Adjusted analyses revealed no differences in mortality (odds ratio [OR], 1.14; 95% confidence interval [CI], 0.34-1.79; p = 0.702) or major complications (OR, 0.87; 95% CI, 0.62-1.87; p = 0.596), while REBOA was associated with higher odds of minor complications (OR, 1.25; 95% CI, 1.01-2.29; p = 0.007).

conclusionResuscitative endovascular balloon occlusion of the aorta provides comparable survival and major complication outcomes to RT in elderly trauma patients, with an increased risk of minor complications. These results suggest that REBOA is a viable alternative to RT, although further studies are needed to optimize patient selection and procedural techniques. LEVEL OF EVIDENCE: Therapeutic/Care Management; Level III.

Indexed as

AortaBalloon OcclusionEndovascular ProceduresHeart ArrestHemorrhageResuscitationWounds and InjuriesAcute Care SurgeryAgedAged, 80 and overFemaleHumansInjury Severity ScoreMaleRegistriesRetrospective StudiesAortic occlusiongeriatricresuscitative endovascular balloon occlusion of the aortaresuscitative thoracotomy

Identifiers

PMID40170237
PMCPMC13488876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.