Evidence map›Paper›PMID 40170113›Full record

ArticleVeterinary research2025

Foot-and-mouth disease virus activates glycolysis and hijacks HK2 to inhibit innate immunity and promote viral replication.

Wenxian Chen, Xinyan Wang, Xiaowen Li, Weijun Wang, Yaoyao Huang, Yuwei Qin, Pengfei Liu, Keke Wu, Bingke Li, Yintao He and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Wenxian Chen *College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Xinyan Wang *College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Xiaowen LiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Weijun WangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Yaoyao HuangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Yuwei QinCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Pengfei LiuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou University, Lanzhou, 730000, China.
Keke WuCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Bingke LiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Yintao HeCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Sen ZengCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Lin YiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Lianxiang WangWen's Foodstuffs Group Co., Ltd., Yunfu, Xinxing, China.
Mingqiu ZhaoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Hongxing DingCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Shuangqi FanCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Zhaoyao LiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China. lizhaoyao123@wens.com.cn.
Jinding ChenCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China. jdchen@scau.edu.cn.ORCID http://orcid.org/0000-0002-5435-0079

Funding

Guangzhou Science and Technology Innovation Center WS-HN-JKYZ-202404-118the Breeding pig healthy and efficient cultivation innovation team CYRC202301the National Key R&D Program of China 2021YFD1800300the Science and Technology Program of Guangzhou, China No. 202206010161
6 · The paper itself

Abstract

Foot-and-mouth disease (FMD) severely restricts the healthy development of global animal husbandry, and the unclear pathogenic mechanism of FMD virus (FMDV) leads to difficulty in preventing and purifying FMD. Glycolytic remodelling is considered one of the hallmarks of viral infection, providing energy and precursors for viral assembly and replication. In this work, the interaction and mechanism between FMDV and glycolysis were explored from the perspective of immune metabolism. We found that FMDV infection increased the extracellular acidification rate, lactic acid accumulation, and HK2 level. In addition, during FMDV infection, HK2 enhances glycolytic activity and mediates autophagic degradation of IRF3/7 to antagonize the innate immune response, thereby promoting viral replication. Our findings provide evidence that FMDV is closely correlated with host metabolism, increasing the understanding that glycolysis and HK2 facilitate virus infection, and provide new ideas for further elucidating the pathogenic mechanism of FMDV.

Indexed as

Foot-and-Mouth DiseaseFoot-and-Mouth Disease VirusGlycolysisHexokinaseImmunity, InnateVirus ReplicationAnimalsHexokinaseFoot-and-mouth disease virusglycolysishexokinase 2interferon regulatory factorreplication

Identifiers

PMID40170113
PMCPMC11963632

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.