Evaluating the protective effects of Aurodox in a murine model of Shiga toxin-producing Escherichia coli.

Rebecca E McHugh, Liam M Rooney, David R Mark, Kabo R Wale, Megan Clapperton, Gail McConnell, Paul A Hoskisson, Gillian R Douce, Andrew J Roe

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in npj antimicrobials and resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Mesolens imaging in microbiology.Essays in biochemistry · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rebecca E McHughSchool of Infection and Immunity, University of Glasgow, Glasgow, UK.

Liam M RooneyStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, UK.

David R MarkSchool of Infection and Immunity, University of Glasgow, Glasgow, UK.

Kabo R WaleSchool of Infection and Immunity, University of Glasgow, Glasgow, UK.

Megan ClappertonStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, UK.

Gail McConnellStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, UK.

Paul A HoskissonStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, UK.

Gillian R DouceSchool of Infection and Immunity, University of Glasgow, Glasgow, UK.

Andrew J RoeSchool of Infection and Immunity, University of Glasgow, Glasgow, UK. andrew.roe@glasgow.ac.uk.

Funding

Glasgow Children's Hospital Charity GCHCRF/PHD/2020/02Royal Academy of Engineering RCSRF2021\11\15UK Research and Innovation BB/T011602/1UK Research and Innovation MR/V011499/1

6 · The paper itself

Abstract

Shiga Toxin-Producing E. coli (STEC) are a group of acute small intestine pathogens responsible for foodborne outbreaks of bloody diarrhoea. The expression of Shiga toxins (Stx) carried by STEC can initiate Haemolytic Uremic Syndrome (HUS), a major cause of acute renal failure in children. Here, we investigate the anti-virulence potential of Aurodox - a natural product of Streptomyces goldiniensis. Previously, we have shown that Aurodox downregulates the expression of the T3SS, inhibiting epithelial cell colonisation in vitro. Here, we use the Citrobacter rodentium DBS770 (Cr Stx2

Identifiers

PMID40169888

DOI10.1038/s44259-025-00094-3

PMCPMC11962119

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.