Evidence map›Paper›PMID 40169805›Full record

ArticleMolecular psychiatry2025

Mettl3 regulates the pathogenesis of Alzheimer's disease via fine-tuning Lingo2.

Xingsen Zhao, Chengyi Ma, Qihang Sun, Xiaoli Huang, Wenzheng Qu, Yusheng Chen, Ziqin Liu, Aimin Bao, Binggui Sun, Ying Yang and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. The Role of NMedComm · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. The mCells · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xingsen Zhao *Department of Genetics and Metabolism, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China.ORCID http://orcid.org/0000-0003-1721-0859
Chengyi Ma *Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
Qihang Sun *Department of Genetics and Metabolism, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China.ORCID http://orcid.org/0009-0001-5419-9110
Xiaoli HuangDepartment of Genetics and Metabolism, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China.
Wenzheng QuDepartment of Genetics and Metabolism, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China.
Yusheng ChenBeijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
Ziqin LiuBinjiang Institute of Zhejiang University, Hangzhou, 310053, China.
Aimin BaoNHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310058, China.ORCID http://orcid.org/0000-0002-8755-1950
Binggui SunDepartment of Genetics and Metabolism, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China. bsun@zju.edu.cn.ORCID http://orcid.org/0000-0002-0386-6569
Ying YangBeijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. yingyang@big.ac.cn.
Xuekun LiDepartment of Genetics and Metabolism, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China. xuekun_li@zju.edu.cn.ORCID http://orcid.org/0000-0002-6985-6363

Funding

Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) D25H090003
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease, and diverse factors contribute to its pathogenesis. Previous studies have suggested the dysregulation of m

Indexed as

Alzheimer DiseaseMembrane ProteinsMethyltransferasesNerve Tissue ProteinsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAnimalsAspartic Acid EndopeptidasesBrainDisease Models, AnimalFemaleHumansMaleMiceMice, TransgenicAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesMembrane ProteinsMethyltransferasesMETTL3 protein, humanMettl3 protein, mouseNerve Tissue ProteinsRNA-Binding Proteins

Identifiers

PMID40169805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.