Evidence map›Paper›PMID 40169792›Full record

ArticleNature genetics2025

Spatially resolved transcriptomic analysis of the adult human prostate.

Junyi Hu, Fei Liu, Jing Zhang, Lei Yin, Wanli Cao, Weidong Xu, Yifan Chang, Ye Wang, Jian Wang, Yaxin Hou and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
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  11. The emerging role of mFrontiers in immunology · 2026
    Review
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Junyi Hu *Department of Urology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID http://orcid.org/0000-0002-7062-6434
Fei Liu *National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. liufei_2359@163.com.ORCID http://orcid.org/0000-0003-1734-7214
Jing Zhang *Department of Pathology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Lei Yin *Department of Urology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Wanli Cao *Department of Urology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Weidong XuDepartment of Urology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Yifan ChangDepartment of Urology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Ye WangDepartment of Urology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Jian WangDepartment of Urology, Affiliated Hospital of Jiangnan University, Wuxi, China.
Yaxin HouDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lilong LiuDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sujun ChenWest China School of Public Health and West China Fourth Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0002-1941-3951
Guanghui ZhuWest China School of Public Health and West China Fourth Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
Junhui JiangTranslational Research Laboratory for Urology, Department of Urology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, China.
Zixian WangMOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, and Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai, China.
Gong-Hong WeiMOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, and Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0001-6546-9334
Housheng Hansen HePrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-2898-3363
Di GuDepartment of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. sveong@163.com.ORCID http://orcid.org/0000-0002-2411-8164
Ke ChenDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. shenke@hust.edu.cn.ORCID http://orcid.org/0000-0002-2098-1921
Shancheng RenDepartment of Urology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China. renshancheng@gmail.com.ORCID http://orcid.org/0000-0001-9205-7888

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prostate is an organ characterized by significant spatial heterogeneity. To better understand its intricate structure and cellular composition, we constructed a comprehensive single-cell atlas of the adult human prostate. Our high-resolution mapping effort identified 253,381 single cells and 34,876 nuclei sampled from 11 patients who underwent radical resection of bladder cancer, which were categorized into 126 unique subpopulations. This work revealed various new cell types in the human prostate and their specific spatial localization. Notably, we discovered four distinct acini, two of which were tightly associated with E-twenty-six transcription factor family (ETS)-fusion-negative prostate cancer. Through the integration of spatial, single-cell and bulk-seq analyses, we propose that two specific luminal cell types could serve as the common origins of prostate cancer. Additionally, our findings suggest that zone-specific fibroblasts may contribute to the observed heterogeneity among luminal cells. This atlas will serve as a valuable reference for studying prostate biology and diseases such as prostate cancer.

Indexed as

Gene Expression ProfilingProstateProstatic NeoplasmsTranscriptomeAdultHumansMaleSingle-Cell Analysis

Identifiers

PMID40169792

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.