Evidence map›Paper›PMID 40169586›Full record

ArticleNature communications2025

Structural insights into the dual Ca

Jia Liu, Cang Wu, Yuyang Liu, Qiangou Chen, Yuzhen Ding, Zhiqiao Lin, Lifeng Pan, Kang Xiao, Jianchao Li, Zhongmin Liu and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jia Liu *Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong, China.
Cang Wu *Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, Guangdong, China.ORCID http://orcid.org/0000-0002-6218-8569
Yuyang LiuShenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong, China.
Qiangou ChenShenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong, China.
Yuzhen DingShenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong, China.
Zhiqiao LinState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
Lifeng PanState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.ORCID http://orcid.org/0000-0002-9229-6288
Kang XiaoShenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong, China.ORCID http://orcid.org/0000-0002-7666-2460
Jianchao LiInnovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, 510006, Guangdong, China. lijch@scut.edu.cn.ORCID http://orcid.org/0000-0002-8921-1626
Zhongmin LiuDepartment of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, Guangdong, China. liuzm@sustech.edu.cn.ORCID http://orcid.org/0000-0002-3280-3890
Wei LiuShenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong, China. liuwei@sphmc.org.ORCID http://orcid.org/0000-0001-8250-2562

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31870746National Natural Science Foundation of China (National Science Foundation of China) 32071219National Natural Science Foundation of China (National Science Foundation of China) 32271270
6 · The paper itself

Abstract

Serine/threonine-protein phosphatases with EF-hands (PPEFs) are a family of highly conserved proteins implicated in cancer and neuronal degeneration. The initially characterized member, Drosophila melanogaster retinal degeneration C (RDGC) contains a calmodulin (CaM)-interacting extended-IQ motif and a Ca

Indexed as

CalciumEF Hand MotifsPhosphoprotein PhosphatasesAmino Acid SequenceAnimalsCell LineDrosophila melanogasterEnzyme ActivationHoloenzymesHumansModels, MolecularProtein BindingProtein Structure, TertiarySequence AlignmentSequence Homology, Amino AcidCalciumHoloenzymesPhosphoprotein Phosphatases

Identifiers

PMID40169586
PMCPMC11962071

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.