Evidence map›Paper›PMID 40169516›Full record

ArticleMolecular neurobiology2025

Melatonin Ameliorates Senescence of Mouse Auditory Cell Line HEI-OC1 Cells by Suppressing NLRP3 Inflammasome-Mediated Pyroptosis.

Yongqing Ding, Yachao Liu, Dong Li, Ruili Hu, Zedong Tian, Lihang Yang, Yanping Li, Yantao Lin, Yan Qu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yongqing DingDepartment of Otolaryngology, Qiaoxi District, The Third Hospital of Hebei Medical University, No. 13, Ziqiang Road, Shijiazhuang City, Hebei Province, China.
Yachao LiuDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Dong LiDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Ruili HuDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Zedong TianDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Lihang YangDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Yanping LiDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Yantao LinDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Yan QuDepartment of Otolaryngology, Qiaoxi District, The Third Hospital of Hebei Medical University, No. 13, Ziqiang Road, Shijiazhuang City, Hebei Province, China. 36500316@hebmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to determine whether oxidative stress-induced premature senescence in mouse auditory cell line HEI-OC1 cells in vitro is associated with NLRP3 inflammasome activation and pyroptosis, and whether melatonin has a protective effect. HEI-OC1 cells were exposed to different concentrations of hydrogen peroxide (H

Indexed as

Cellular SenescenceInflammasomesMelatoninNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisAnimalsCaspase 1Cell LineHydrogen PeroxideMiceOxidative StressCaspase 1Hydrogen PeroxideInflammasomesMelatoninNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseCochlear hair cellsGSDMDMelatoninNLRP3Pyroptosis

Identifiers

PMID40169516
PMCPMC12289756

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.