Evidence map›Paper›PMID 40169491›Full record

ArticleOphthalmology and therapy2025

Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Dry Eye Disease: A Systematic Review with Meta-analysis.

Antonio Ballesteros-Sánchez, Carlos Rocha-de-Lossada, José-María Sánchez-González, Giovanni Roberto Tedesco, Davide Borroni

Abstract read
In one paragraph

Article in Ophthalmology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Antonio Ballesteros-SánchezSchool of Optics and Optometry, Carrer del Violinista Vellsola, Universitat Politècnica de Catalunya, 08222, Terrassa, Spain. antonio.ballesteros@upc.edu.ORCID http://orcid.org/0000-0002-9248-8685
Carlos Rocha-de-LossadaOphthalmology Department, VITHAS Malaga, 29016, Malaga, Spain.
José-María Sánchez-GonzálezDepartment of Physics of Condensed Matter, Optics Area, University of Seville, 41012, Seville, Spain.
Giovanni Roberto TedescoCentro Oculistico Tedesco, 88024, Girifalco, Italy.
Davide BorroniRiga Stradins University, Riga, 1007, Latvia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to investigate the efficacy and safety of quantum molecular resonance (QMR) electrotherapy in patients with dry eye disease (DED).

methodsA systematic review with meta-analysis, reporting the effects of QMR electrotherapy in three databases, PubMed, Scopus and Web of Science, was performed according to the PRISMA statement with a search period ending on December 24, 2024.

resultsSeven studies, including four open-label, non-comparative trials and three randomized controlled studies (RCTs), were included. Although all studies reported significant improvements in most outcome measures after QMR electrotherapy, the meta-analysis indicated that overall efficacy did not significantly favor either group when comparing QMR electrotherapy to controls (SMD 0.40; 95% CI - 0.06 to 0.86; P = 0.09; I

conclusionsWith the current scientific literature available to date, QMR electrotherapy seems to show some evidence of alleviating DED symptoms. However, evidence supporting its efficacy in improving DED signs and safety remains limited. Therefore, further RCTs with robust designs are needed to confirm these findings.

Indexed as

Dry eye diseaseQuantum molecular resonance electrotherapyRexon-EyeTranscutaneous electrical stimulation

Identifiers

PMID40169491
PMCPMC12006613

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.