Evidence map›Paper›PMID 40169421›Full record

ArticleEthnicity & health2025

The association of discrimination, inflammation, and coping style on self-rated health among South Asian individuals in the MASALA Study.

Raji Pillai, Sahiti Myneni, Constance M Johnson, Nilay S Shah, Alka M Kanaya, Jennifer E S Beauchamp

Abstract read
In one paragraph

Article in Ethnicity & health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Raji PillaiCizik School of Nursing, University of Texas Health Science Center at Houston, Houston, TX, USA.
Sahiti MyneniMcWilliams School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA.
Constance M JohnsonCizik School of Nursing, University of Texas Health Science Center at Houston, Houston, TX, USA.
Nilay S ShahDepartment of Medicine (Cardiology), Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Alka M KanayaDivision of General Internal Medicine, University of California, San Francisco CA, USA.
Jennifer E S BeauchampCizik School of Nursing, University of Texas Health Science Center at Houston, Houston, TX, USA.

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Research Design, Data, and Analytics CoreP30DK092949 · NIDDK · UNIVERSITY OF CHICAGO · PI MARSHALL H CHIN · 2011 to 2026
$10.0M
Mediators of Atherosclerosis in South Asians Living in AmericaR01HL093009 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2010 to 2018
$5.4M
Ectopic fat and atherosclerosis in South AsiansK24HL112827 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2013 to 2022
$1.2M
NCATS NIH HHS UL1 TR001872NCRR NIH HHS UL1 RR024131NHLBI NIH HHS K24 HL112827NHLBI NIH HHS R01 HL093009NIDDK NIH HHS P30 DK092949
6 · The paper itself

Abstract

objectivesSouth Asian individuals (SAs) may have heightened levels of inflammatory markers, such as C reactive protein (CRP), Tumor Necrosis Factor-α (TNF-α), leptin, and resistin, and decreased levels of anti-inflammatory adiponectin, contributing to higher cardiovascular disease (CVD) incidence. Social determinants of health, like discrimination, are also associated with risks for CVD in SAs. This study examined the associations between discrimination and inflammation and whether coping styles moderated the association between discrimination and self-rated health (SRH) among SAs in the United States.

designSecondary analysis of data obtained from 1164 SAs (mean age = 57 years, SD = 9.4, 48% women) enrolled in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study was conducted. Discrimination was measured using the Everyday Discrimination Scale (EDS). Inflammatory markers (CRP, TNF-α, leptin, resistin) and anti-inflammatory adiponectin were measured from blood samples. SRH was self-reported by participants. Coping styles were defined as problem-focused or emotion-focused. Multiple regression with bootstrapping was used to examine associations between discrimination and inflammatory markers and adiponectin. Moderation analysis assessed whether coping styles moderated the association between discrimination and SRH.

resultsNo significant associations were found between discrimination and inflammation. Discrimination was inversely associated with SRH (OR = 0.969,

conclusionThe unknown magnitude and duration, and the lack of variability in discrimination among participants could explain the null findings between discrimination and inflammation. Gaining a better understanding of the ways in which SAs appraise and cope with discriminatory experiences may help to develop future interventions targeted to reduce the adverse health consequences of discrimination among SAs.

Indexed as

Adaptation, PsychologicalAsianEmigrants and ImmigrantsHealth StatusInflammationAdiponectinAgedAsia, SouthernBiomarkersC-Reactive ProteinFemaleHumansLeptinMaleMiddle AgedResistinAdiponectinBiomarkersC-Reactive ProteinLeptinResistinTumor Necrosis Factor-alphacoping stylediscriminationGood health and well-beinginflammatory markersMASALAReduced inequalitiesself-rated healthSouth AsianSustainable cities and communities

Identifiers

PMID40169421
PMCPMC13401951

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.