Evidence map›Paper›PMID 40169405›Full record

ArticleArchives of virology2025

Identification of a recombinant GII.13[P21] norovirus strain: molecular dynamic simulations indicate that gene mutations shifted its spectrum of binding to host receptor glycans.

Yunfei Chen, Zexian Zhou, Lei Dong, Miao Jin, Yongjie Wang, Yongxin Yu

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yunfei ChenCollege of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
Zexian ZhouCollege of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
Lei DongCollege of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
Miao JinNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Yongjie WangCollege of Food Science and Technology, Shanghai Ocean University, Shanghai, China. yjwang@shou.edu.cn.
Yongxin YuCollege of Food Science and Technology, Shanghai Ocean University, Shanghai, China. yxyu@shou.edu.cn.ORCID http://orcid.org/0000-0002-1447-2880

Funding

National Natural Science Foundation of China 31601570National Natural Science Foundation of China 32370151Science and Technology Innovation Plan Of Shanghai Science and Technology Commission 22N31900700
6 · The paper itself

Abstract

Human norovirus is a pervasive pathogen that causes global outbreaks of viral gastroenteritis. Previous studies have suggested that histo-blood group antigens (HBGAs) can interact with human norovirus, facilitating its entry of host cells and significantly affecting its evolution. In this study, the complete genome sequence of recombinant GII.13[P21] norovirus from fecal samples was analyzed. Molecular dynamics simulations of GII.13 norovirus P proteins from 1978 to 2019 showed changes in their capacity to bind to HBGAs. Initially, GII.13 proteins bound A or B/H-type HBGAs, but subsequent mutations resulted in a loss of this binding capacity, favoring binding to the HBGA type I precursor (Lewis c) over A or B/H and Lewis antigens.

Indexed as

Blood Group AntigensCaliciviridae InfectionsNorovirusPolysaccharidesFecesGastroenteritisGenome, ViralHumansMolecular Dynamics SimulationMutationProtein BindingBlood Group AntigensPolysaccharides

Identifiers

PMID40169405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.