Evidence map›Paper›PMID 40169401›Full record

ArticlePrenatal diagnosis2025

Assessment of Fetal Cardiac Geometry and Systolic Function in Fetuses With Ventricular Septal Defect During the Second Trimester Using Fetal Heart Quantification Technology.

Li Hou, Dongmei Zhang, Chunrong Li, Liuying Zhou, Shiyue Peng, Lixue Yin, Tongyong Luo

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Article in Prenatal diagnosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Li HouSchool of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Dongmei ZhangSchool of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Chunrong LiSchool of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Liuying ZhouSchool of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Shiyue PengCity University of Hong Kong, Hong Kong, China.
Lixue YinSichuan Academy of Medical Sciences, Sichuan Provincial Key Laboratory of Ultrasound Cardiac Electrophysiology and Biomechanics, Sichuan Provincial People's Hospital, Chengdu, China.
Tongyong LuoSichuan Provincial Maternity and Child Health Care Hospital, Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China.ORCID 0000-0002-0184-8287

Funding

Sichuan Academy of Medical SciencesSichuan Provincial Key Laboratory of Ultrasound Cardiac Electrophysiology and Biomechanics 2022KFKT03Sichuan Provincial People's Hospital
6 · The paper itself

Abstract

objectiveThis study aimed to assess the impact of ventricular septal defect (VSD) on fetal cardiac geometry and systolic function during the second trimester using Fetal Heart Quantification (Fetal HQ) technology.

methodsIn this prospective study, 91 fetuses with isolated VSD and 91 gestational age-matched healthy controls were evaluated. Using the GE Voluson E10 ultrasound system and Fetal HQ software, cardiac parameters such as global sphericity index (GSI), global longitudinal strain (GLS), ejection fraction (EF), and fractional area change (FAC) were measured. Segmental end-diastolic diameters (EDD) and sphericity indices (SI) for both ventricles were analyzed. Statistical analyses compared groups and assessed correlations between VSD size and left ventricular function.

resultsThe VSD group displayed significant reductions in left ventricular segmental EDD and increases in right ventricular SI, reflecting localized geometric changes. Left ventricular GLS, EF, FAC, and stroke volume were notably reduced in the VSD group, indicating compromised function. VSD size negatively correlated with left ventricular GLS and FAC.

conclusionVSD significantly affects left ventricular geometry and function, with larger defects showing greater impairment. Fetal HQ technology effectively characterizes these changes, aiding early diagnosis and enabling personalized perinatal management.

Indexed as

Fetal HeartHeart Septal Defects, VentricularUltrasonography, PrenatalAdultCase-Control StudiesEchocardiographyFemaleHumansPregnancyPregnancy Trimester, SecondProspective StudiesSystole

Identifiers

PMID40169401
PMCPMC12054389

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.