ArticleObesity (Silver Spring, Md.)2025
Effects of weight loss on testosterone, sex hormone-binding globulin, adiposity, and insulin sensitivity in women and men.
Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Cagrilintide and retatrutide combination therapy enhances weight loss and metabolic outcomes in obese male rats.Nature metabolism · 2026Article
- Urinary metabolomic profiling to identify the impact of the increased intake of whole grains, vegetables, and fruits in healthy adolescents.European journal of clinical nutrition · 2026Article
- Sexual Dimorphism in the Relationship between Body Composition and Insulin Resistance in Older Adults.Current developments in nutrition · 2026Article
- Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan.Frontiers in endocrinology · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveTestosterone and glucose disposal (Rd) are positively associated in adult men, whereas the opposite is reported in women. Sex-specific relationships between testosterone or sex hormone-binding globulin (SHBG) and Rd in men and women with and without obesity and following weight loss were examined.
methodsAdult men and women (n = 27/28; BMI = 20-41 kg/m
resultsBioA testosterone was lower in men with obesity and was related to Rd positively in men and negatively in women (p < 0.05). Across participants, weight loss increased Rd and SHBG (p < 0.01). BioA testosterone was unchanged in men; however, individual changes were independently related to Rd (p = 0.031). In women, BioA testosterone declined (p < 0.009) but was not related to Rd.
conclusionsBioA testosterone was associated with Rd, positively in men and negatively in women. Weight loss reduced BioA testosterone in women; however, individual changes were associated with improved Rd in men. SHBG was a better correlate of improved Rd in women. Additional studies should identify mechanisms that drive sex differences and interventions that modify testosterone, reduce adiposity, and improve Rd across both sexes.
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Registered trials
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