SynthesisCells, tissues, organs2025
Anatomy, Histology, Aetiology, Development and Functions of Cartilago Cordis: A Systematic Review.
Synthesis in Cells, tissues, organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
Funding
Abstract
introductionThe cartilago cordis is a structure present within the cardiac skeleton of some, but not all, vertebrate species. This systematic review compared the presence, structure, and function of the cartilago cordis from published works covering all vertebrate species.
methodsLiterature searches were conducted to obtain information relating to the anatomical location, morphology, prevalence, number of structures, development, and function.
resultsThe cartilago cordis was most commonly composed of hyaline cartilage but its location within the cardiac skeleton, anatomical, and histological structure varied between species. The cartilago cordis has not been documented in every vertebrate species, or every individual within each species, but it is present in 68 vertebrates including an amphibian, and some mammals, reptiles, and birds. The function of the cartilago cordis is unknown, but theories have ranged from an adaptive mechanism to support cardiac tissue through to roles in conduction and contraction, especially in areas of high mechanical stress. Possible links between the presence of a cartilago cordis and cardiac pathologies were also identified.
conclusionThe cartilago cordis varied in prevalence, structure, and location; further research is required to understand the function and development. In addition, it is possible there are more vertebrate species containing cartilago cordis than presently known about given its varying prevalence and sometimes small size.
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