ArticlePloS one2025
Dynamic changes and metabolic function of intestinal flora in patients with postoperative pneumonia after lung cancer surgery.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effectiveness of electrical stimulation for postoperative rehabilitation of lung cancer: a systematic review and meta-analysis.Journal of thoracic disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative pneumonia (POP) is the most prevalent postoperative complication following lung cancer surgery. It is a crucial factor that influences surgical success and the rapid recovery of patients. Studies on the gut-lung axis have suggested that changes in the structural and functional aspects of intestinal flora are implicated in the incidents and development of pulmonary infection. This study aims to reveal the dynamic changes and metabolic function of intestinal flora in lung cancer patients with POP, with the ultimate goal of providing novel insights and targets for the prevention and treatment of POP.
methodsThis study includes three groups: healthy control group, lung cancer with POP group, and lung cancer without POP group. We collected stool samples from healthy individuals, preoperative and first post-infection stool samples from the POP group, and preoperative and first postoperative stool samples from the non-POP group. The hypervariable V3-V4 regions of 16S rRNA gene were sequenced using Illumina MiSeq high-throughput sequencing technology.
resultsThe alpha diversity index was lower in the POP group than in the healthy group, the beta diversity index was also different between the two groups (P < 0.05). Eggerthella, Coprobacillus, and Peptostreptococcus were abundant in the intestinal tracts of the POP group in preoperative and postoperative infections. There was a decrease in the abundance of beneficial genera such as Blautia and an increase in the abundance of pathogenic or opportunistic pathogens such as Bacteroides. The phosphatidylinositol signaling system abundance increased, whereas the abundance of phenazine, phenylalanine, tyrosine, and tryptophan biosyntheses was reduced in the POP group during postoperative infection.
conclusionPatients with POP after lung cancer surgery have a distinct spectrum of intestinal flora. The intestinal flora displays a reduction in diversity and an increase in the presence of potential pathogenic bacteria, which impact metabolic functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.