Evidence map›Paper›PMID 40168130›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The TRPV3 channel is a mediator of zinc influx and homeostasis in murine oocytes.

Emily M Lopes, Hiroki Akizawa, Oguz C Koc, Edgar Soto-Moreno, Neha Gupta, Goli Ardestani, Ahmed Z Balboula, Ingrid Carvacho, Rafael A Fissore

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emily M LopesDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.ORCID 0000-0003-0476-3665
Hiroki AkizawaDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.
Oguz C KocDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.ORCID 0009-0005-7320-2230
Edgar Soto-MorenoDivision of Animal Sciences, University of Missouri, Columbia, MO 65211.ORCID 0000-0002-1925-2940
Neha GuptaDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.
Goli ArdestaniDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.ORCID 0000-0002-2599-5361
Ahmed Z BalboulaDivision of Animal Sciences, University of Missouri, Columbia, MO 65211.ORCID 0000-0001-9663-6262
Ingrid CarvachoDepartment of Translational Medicine, Faculty of Medicine, Universidad Catolica del Maule, Talca, Maule 3460000, Chile.ORCID 0000-0003-2311-7239
Rafael A FissoreDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003.ORCID 0000-0001-5655-0915

Funding

Mechanisms underpinning meiotic spindle formation and behaviorR35GM142537 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI AHMED BALBOULA · 2021 to 2026
$2.7M
Regulation of the functional expression of the TRPM7 chanzyme essential for Mg2+ homeostasis in mouse oocytes and cleaving embryos to improve assisted reproductive technologies and modulate fertilityR01HD092499 · NICHD · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Rafael Antonio Fissore · 2018 to 2026
$2.0M
Comparative analysis of molecular events in mammalian oocytesR01HD113358 · NICHD · UNIVERSITY OF MISSOURI-COLUMBIA · PI AHMED BALBOULA · 2023 to 2026
$1.3M
Mammalian Fertilization: Identifying the second sperm factor that induces residual calcium oscillations and its contributions to egg activationR21HD110734 · NICHD · UNIVERSITY OF MASSACHUSETTS AMHERST · PI FISSORE, RAFAEL ANTONIO · 2023 to 2024
$430k
ANID | Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 1221308HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD092499HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD110734HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD113358HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM142537NICHD NIH HHS R01 HD092499NICHD NIH HHS R01 HD113358NICHD NIH HHS R21 HD110734NIGMS NIH HHS R35 GM142537
6 · The paper itself

Abstract

Zinc (Zn

Indexed as

HomeostasisOocytesTRPV Cation ChannelsZincAnimalsCalciumFemaleMiceMice, KnockoutCalciumTrpv3 protein, mouseTRPV Cation ChannelsZincactinfertilizationoocyte maturationTrp channelswhole-cell patch clamp

Identifiers

PMID40168130
PMCPMC12002305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.