Evidence map›Paper›PMID 40168119›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Design of a halogen bond catalyzed DNA endonuclease.

Margaret G Walker, Cesar Gustavo Mendez, Alexander N Ho, Ryan S Czarny, Anthony K Rappé, Pui Shing Ho

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Probing Weak Halogen Bonding in Aqueous Solution.Journal of the American Chemical Society · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Margaret G Walker *Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870.
Cesar Gustavo Mendez *Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870.
Alexander N Ho *Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870.
Ryan S CzarnyDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870.
Anthony K RappéDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523-1872.ORCID 0000-0002-5259-1186
Pui Shing HoDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870.ORCID 0000-0002-8082-4311

Funding

NSF (NSF) CHE-220316NSF (NSF) MCB-2124202
6 · The paper itself

Abstract

In this study, we expand the repertoire of biological catalysts by showing that a halogen bond (X-bond) can functionally replace the magnesium (Mg

Indexed as

EndodeoxyribonucleasesHalogensAnimalsCatalysisCatalytic DomainEdetic AcidHydrogen BondingMagnesiumMiceModels, MolecularTyrosineEdetic AcidEndodeoxyribonucleasesHalogensMagnesiumTyrosineDNA endonucleaseenzyme catalysishalogen bondprotein design

Identifiers

PMID40168119
PMCPMC12002254

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.