ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
The Association of Circulating Immune Cells With Cognitive Function, Brain Imaging, and Incident All-cause and Alzheimer's Dementia: The Framingham Offspring Study.
Yumeng Cao, Lindsay R Salvati, Jiachen Chen, Ahmed Ragab, Jesse Mez, Claudia L Satizabal, Michael L Alosco, Yuan Fang, Wei Qiao Qiu, Kathryn L Lunetta and 2 more
Abstract read
In one paragraphArticle in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Yumeng CaoDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Lindsay R SalvatiDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Jiachen ChenDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-1941-2326 Ahmed RagabDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Jesse MezBoston University Alzheimer's Disease Research Center, BU CTE Center, Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.
Claudia L SatizabalFramingham Heart Study, National Heart, Lung, and Blood Institute and Boston University Chobanian and Avedisian School of Medicine, Framingham, Massachusetts, USA.ORCID 0000-0002-1115-4430 Michael L AloscoBoston University Alzheimer's Disease Research Center, BU CTE Center, Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-8113-8428 Yuan FangSchool of Pharmacy and Pharmaceutical Sciences, Binghamton University, State University of New York, Binghamton, New York, USA.ORCID 0000-0001-8430-1238 Wei Qiao QiuBoston University Alzheimer's Disease Research Center, BU CTE Center, Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.
Kathryn L LunettaDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-9268-810X Joanne M MurabitoFramingham Heart Study, National Heart, Lung, and Blood Institute and Boston University Chobanian and Avedisian School of Medicine, Framingham, Massachusetts, USA.
Margaret F DoyleDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.ORCID 0000-0001-6769-5386 Funding
TBDU19AG068753 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ting Fang Alvin Ang · 2020 to 2026
$42.4MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MEPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4MMRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MMRI, Cognitive, Genetic & Biomarker Precursors of AD & Dementia in Young AdultsR01AG033040 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 2009 to 2019
$11.2MLeveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD)R01AG061028 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN, MEZ, JESSE BENJAMIN · 2019 to 2023
$5.9MCollaborative GWAS of Dementia, AD and related MRI and Cognitive EndophenotypesR01AG033193 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SESHADRI, SUDHA · 2009 to 2016
$4.4MRole of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring StudyR01AG067457 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DOYLE, MARGARET F., LUNETTA, KATHRYN L · 2020 to 2024
$3.4MPreclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young AdultsR01AG049607 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2015 to 2019
$3.1MBUSPH Interdisciplinary Training Program for BiostatisticiansT32GM140972 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Kathryn L Lunetta, Laura Forsberg White · 2021 to 2026
$1.9MNIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG033040NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG061028NIA NIH HHS R01 AG067457NIA NIH HHS U19 AG068753NIGMS NIH HHS T32 GM140972NIH HHS R01AG016495NIH HHS R01AG033040NIH HHS R01AG033193NIH HHS R01AG049607NIH HHS R01AG054076NIH HHS R01AG067457NIH HHS R01AG08122NIH HHS R01NS017950NIH HHS T32GM140972NIH HHS U19 AG068753NINDS NIH HHS R01 NS017950
6 · The paper itselfAbstract
Emerging evidence supports the central role of the immune system in brain health, yet little is known about the role of circulating immune cells and cognitive function or brain health in dementia-free populations. We investigated the association of 43 immune cells with cognitive function, structural brain imaging, and incident dementia in Framingham Heart Study Offspring participants. Immune cells were phenotyped by flow cytometry. Linear mixed effects models were used for cross-sectional associations between immune cells and 4 cognitive domain scores and 13 brain magnetic resonance imaging measurements. Cox proportional hazards regression models tested the relationship between immune cells and time to dementia. Models were adjusted for age, sex, education, cytomegalovirus status, and APOE genotype, with further adjustment for cardiovascular risk factors. Data was further stratified by cytomegalovirus status. Among 795 participants with cellular phenotyping, cognitive testing and brain imaging data (mean age 61, 52% women), there were no associations between immune cells and cognitive test scores. Several significant associations between immune cells and regional brain magnetic resonance imaging measurements were observed. Higher CD8+ cells [CD8+CD45RO-CCR7-CD27- (Teff), CD8+CD45RA+CD28-CD57+(TEMRA), CD8+CD27-CD28-] associated with greater cerebrum gray and frontal gray matter volumes and inclusion of cardiovascular risk factors strengthened the association. Among CMV+ participants, CD8+TEMRA and CD8+Teff cells were significantly associated with higher total gray and frontal gray matter volumes. No significant associations were observed between immune cells and incident all-cause or Alzheimer's disease dementia. The pathobiology underpinning the associations between immune cells and brain volumes require further study and validation in diverse samples.
Indexed as
Alzheimer DiseaseBrainCognitionAgedCross-Sectional StudiesFemaleHumansIncidenceMagnetic Resonance ImagingMaleMiddle AgedRisk FactorsBrain MRIImmunityT cells
Identifiers
PMID40168089
PMCPMC12128850
What OpenQuestion holds
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