ArticleThe Journal of physiology2025
Neuron-non-neuron electrical coupling networks are involved in chronic stress-induced electrophysiological changes in lateral habenular neurons.
Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Cell Type-Specific Downregulation of Dnmt3a in Nucleus Accumbens Oligodendrocytes Prevents Myelin Damage and Reduces Susceptibility to Social Stress in Male Mice.Biomolecules · 2026Article
- Multiple bursting patterns in lateral habenula neurons: Experiments and computational model.The Journal of physiology · 2026Article
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13 authors.
Funding
Abstract
The lateral habenula (LHb) is a key brain structure that receives input from higher brain regions and regulates monoaminergic activity. LHb hyperactivity has been implicated in the pathophysiology of depression, but the electrophysiological mechanisms underlying this hyperactivity remain poorly understood. To address this issue, we investigated how chronic stress alters the firing properties of LHb neurons in a mouse model of chronic social defeat. Whole-cell recordings were conducted from LHb neurons in the mouse acute brain slices. LHb neurons exhibited two types of rebound depolarizing potentials (RDPs) after the offset of hyperpolarization: short-RDPs (lasting <400 ms) and long-RDPs (order of seconds). Stress-susceptible mice showed a significantly reduced occurrence of long-RDPs, whereas spike firing in response to depolarizing current injections remained unchanged. Both short- and long-RDPs were triggered by T-type voltage-dependent Ca
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