ArticleNeuroinformatics2025
Revealing the Multivariate Associations Between Autistic Traits and Principal Functional Connectome.
Article in Neuroinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Multimodal Representation Learning for Parsing Biological Heterogeneity in Psychiatric Neuroimaging.Biological psychiatry · 2026Review
- A Complex Network-Based Approach for Detecting and Characterizing Power Neurons in Drosophila.Neuroinformatics · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Autism Spectrum Disorder (ASD) is a multifaceted neurodevelopmental condition characterized by a spectrum of behavioral and cognitive traits. As the characteristics of ASD are highly heterogeneous across individuals, a dimensional approach that overcomes the limitation of the categorical approach is preferred to reveal the symptomatology of ASD. Previous neuroimaging studies demonstrated strong links between large-scale brain networks and autism phenotypes. However, the existing studies have primarily focused on univariate association analysis, which limits our understanding of autism connectopathy. Using resting-state functional magnetic resonance imaging data from 309 participants (168 individuals with ASD and 141 typically developing controls) across a discovery dataset and two independent validation datasets, we identified multivariate associations between high-dimensional neuroimaging features and diverse phenotypic measures (20 or 7 measures). We generated low-dimensional representations of functional connectivity (i.e., gradients) and assessed their multivariate associations with autism-related phenotypes of social, behavioral, and cognitive problems using sparse canonical correlation analysis (SCCA). We selected three functional gradients that represented the cortical axes of the sensory-transmodal, motor-visual, and multiple demand-rests of the brain. The SCCA revealed multivariate associations between gradients and phenotypic measures, which were noted as linked dimensions. We identified three linked dimensions: the links between (1) the first gradient and social impairment, (2) the second and internalizing/externalizing problems, and (3) the third and metacognitive problems. Our findings were partially replicated in two independent validation datasets, indicating robustness. Multivariate association analysis linking high-dimensional neuroimaging and phenotypic features may offer promising avenues for establishing a dimensional approach to autism diagnosis.
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Registered trials
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