Observational studyLa Radiologia medica2025
Interrater reliability of MRI Neck Imaging Reporting and Data System (NI-RADS) in the follow-up of nasopharyngeal carcinoma after radiation therapy.
Observational study in La Radiologia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Inter-rater reliability of MRI Neck Imaging Reporting and Data System (NI-RADS) in the follow-up of oropharyngeal squamous cell carcinoma.La Radiologia medica · 2026Observational
- Use of gadolinium-based contrast agents in head and neck cancer diagnosis, staging, and monitoring: current applications and future perspectives.European radiology · 2026Review
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7 authors.
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Abstract
purposeEvidence supporting the reliability of magnetic resonance imaging (MRI) Neck Imaging Reporting and Data System (NI-RADS) is currently limited. This study aims to evaluate the interrater agreement of MRI NI-RADS among radiologists with varying levels of expertise in nasopharyngeal carcinoma (NPC) patients. MATERIAL AND
methodsWe designed an observational retrospective study to identify follow-up MRIs in patients who had undergone radiation therapy. Five radiologists (2 head and neck experts, 1 general radiologist, and 2 residents in radiology) scored each MRI using NI-RADS. Kappa (κ) and percentage of agreement (POA) were calculated for the ultimate score and for each individual feature of the NI-RADS (primary tumor size, signal on T2-weighted images, contrast enhancement, diffusion restriction, and lymph node size). Agreement was analyzed also separately for the first follow-up MRI and subsequent scans.
resultsThirty patients were included (a total of 97 MRIs per rater). Interreader agreement between all readers was moderate for NI-RADS (κ = 0.41; POA = 81%). The first follow-up showed a low reliability between the head and neck expert radiologist and the two radiology residents for both primary tumor contrast enhancement and size assessment (κ = 0.02; POA = 31% and κ = 0.17; POA = 38%, respectively), while there was a high level of agreement in the analysis of diffusion-weighted imaging (DWI) (κ = 0.79; POA = 96%).
conclusionMRI NI-RADS has a moderate interrater agreement in NPC patients after radiation therapy. Educational effort should focus on the assessment and interpretation of primary tumor contrast enhancement and size in the first examination performed after treatment, by also considering information derived from DWI.
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