ArticleMethods in molecular biology (Clifton, N.J.)2025
Monitoring Cerebrospinal Fluid Inflammatory Mediators by Olink Target 48 Cytokine Panel.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Percutaneous Coronary Intervention for Chronic Total Occlusions Modulates Cardiac Hypoxic and Inflammatory Stress.Journal of clinical medicine · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diagnosis and monitoring of neurological disorders are challenging due to their complexity and the difficulty of obtaining samples of damaged tissue while the patient is alive. Cerebrospinal fluid (CSF) is an excellent biofluid for conducting diagnostic and monitoring studies because it is in direct contact with the brain, allowing for the analysis of secreted proteins and peptides associated with various neurological disorders.The Proximity Extension Assay, which combines antibodies with oligonucleotides to detect proteins via qPCR, is revolutionizing the field of biomarker identification. The Olink Target 48 Cytokine Panel is an optimal tool for evaluating the inflammatory profile of CSF samples, requiring only one microliter. The workflow involves incubation with antibody-linked oligonucleotides, extension, amplification through a PCR assay, and detection using microfluidic qPCR, enabling precise and accurate quantification of cytokine levels in pg/mL. This approach offers valuable insights into inflammatory processes within the CSF, serving as a robust tool for studying and understanding inflammation in neurological contexts.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.