ArticleMethods in molecular biology (Clifton, N.J.)2025
Application of Single Molecule Array (SIMOA) in Cerebrospinal Fluid.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Nanomaterial-enhanced biosensors for traumatic brain injury biomarker detection: a review of analytical performance, machine learning integration, clinical validation, and point-of-care translation.Frontiers in neurology · 2026Review
- UCH-L1 in Alzheimer's Disease: A Crucial Player in Dementia-Associated Mechanisms.International journal of molecular sciences · 2025Review
- Cross-platform analytical assessment of serum GFAP quantification in multiple sclerosis: SIMOA versus two automated immunoassays.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SIMOA is a highly sensitive immunoassay technology used for the ultrasensitive detection and quantification of specific biomolecules, typically proteins, in various biological samples. It utilizes antibody-coated beads and fluorescently conjugated detection antibodies that are applied within the samples to a specialized cartridge with microwells, allowing for single-molecule detection. Due to its ability to detect and quantify biomolecules at extremely low concentrations, SIMOA is used in medical and biological research, and diagnostics for various biomarkers, including those related to cancer, neurodegenerative diseases, and cardiovascular conditions. In this chapter, we described the method to monitor cerebrospinal fluid (CSF) biomarkers as a valuable tool in early disease detection and monitoring.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.