Evidence map›Paper›PMID 40167853›Full record

Trial reportSleep & breathing = Schlaf & Atmung2025

Impact of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial.

Siraj Omar Wali, Ghadah Batawi, Omar Kanbr, Nadeem Shafique Butt, Murad A Yasawy, Dalyah Alqaidi, Faris Alhejaili, Ranya Alshumrani, David Gozal

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05471765 (Effects of Continuous Positive Airway Pressure Therapy Withdrawal in Patients With Obstructive Sleep Apnea), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05471765 naunknown statusnot on this map

Effects of Continuous Positive Airway Pressure Therapy Withdrawal in Patients With Obstructive Sleep Apnea: A Randomized Trial

TypeinterventionalSponsorKing Abdulaziz UniversityRan2020 to 2022Enrolled60ConditionsObstructive Sleep ApneaArmsWithdrawal of Continuous Positive Airway Pressure device, Alternation usage of Continuous Positive Airway Pressure Device
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siraj Omar WaliRespiratory Section, Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. sowali@kau.edu.sa.ORCID 0000-0002-5825-5642
Ghadah BatawiSleep Medicine Research Group, Sleep Medicine and Research Center, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Omar KanbrSleep Medicine Research Group, Sleep Medicine and Research Center, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Nadeem Shafique ButtDepartment of Family and Community Medicine, Faculty of Medicine Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
Murad A YasawyEmergency Medicine, King Abdullah University Hospital, Irbid, Jordan.
Dalyah AlqaidiSleep Medicine Research Group, Sleep Medicine and Research Center, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Faris AlhejailiRespiratory Section, Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Ranya AlshumraniSleep Medicine Research Group, Sleep Medicine and Research Center, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
David GozalDean of Joan C Edwards School of Medicine, Vice-President for Health Affairs, Marshall University, Huntington, USA.

Funding

King Abdulaziz University IFPRC-128-140-2020
6 · The paper itself

Abstract

purposeContinuous positive airway pressure (CPAP) is the gold standard for managing moderate-to-severe obstructive sleep apnea (OSA). However, adherence to CPAP usage remains problematic with many patients either intermittently or permanently discontinuing CPAP use. However, the impact of CPAP therapy discontinuation remains unclear. This study aimed to evaluate the effects of complete and intermittent CPAP withdrawal on clinical and objective relapse of OSA. PATIENTS AND

methodsThis randomized study involved patients with moderate-to-severe OSA who were compliant with CPAP therapy. All subjects underwent a CPAP efficacy assessment (CPAP check), followed by 1 month of closely monitored CPAP usage. Subjects were then randomized into two groups: (1) complete CPAP withdrawal (NO-CPAP); (2) intermittent CPAP use (INT-CPAP) (using the device every other day). Clinical relapse was assessed daily and defined as reemergence of any of the OSA symptoms. Weekly home sleep testing was performed to assess OSA relapse objectively, defined as an apnea-hypopnea index (AHI) of > 5.

resultsA total of 22 patients were included, with 12 subjects assigned to NO-CPAP group and 10 to the INT-CPAP group. Both groups exhibited a rapid recurrence of OSA within 1 week of CPAP discontinuation, with significant increases in AHI, oxygen desaturation index, and time spent with O

conclusionDiscontinuation of CPAP therapy, whether completely or intermittently, leads to rapid OSA relapse, with age and neck circumference being key predictors of OSA relapse. These findings underscore the impact of CPAP withdrawal and the need for continuous CPAP adherence to effectively manage OSA. CLINICAL

trial registrationA full trial protocol can be accessed through: https://clinicaltrials.gov/study/NCT05471765 .

Indexed as

Continuous Positive Airway PressurePatient ComplianceSleep Apnea, ObstructiveAdultFemaleHumansMaleMiddle AgedPolysomnographyRecurrenceCPAPIntermittentObstructive sleep apneaRelapseWithdrawal

Identifiers

PMID40167853

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.