Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Association of GI symptoms with health-related quality of life in cancer patients undergoing chemotherapy: a prospective study.
Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Medical Gaslighting in Gastroenterology: A Narrative Review From Pediatric and Adult Practice.Gastro hep advances · 2026Review
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Authors and funding
5 authors.
Funding
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Abstract
purposeChemotherapy, a primary cancer treatment, often leads to debilitating gastrointestinal (GI) side effects, significantly impacting health-related quality of life (HRQoL). This study investigates the prevalence and impact of gastrointestinal (GI) symptoms on HRQoL in cancer patients undergoing chemotherapy in Bihar, India.
methodsThis prospective observational study enrolled 246 chemotherapy patients (≥ 18 years) over 9 months. GI symptoms and HRQoL were assessed using the Gastrointestinal Symptom Rating Scale (GSRS) and Short Form-36 (SF-36) questionnaires. Data analysis employed SPSS v.27, with t-tests determining significant associations.
resultsMild GI symptoms were prevalent (72.8% reported mild pain; 84.6% reported mild heartburn), while severe nausea (81.7%) and diarrhea (56.1%) were notable. A significant correlation existed between symptom severity and HRQoL decline (t = 15.35, p < 0.01). Severe symptoms substantially reduced HRQoL, particularly in pain (from 498.2 to 464.2), heartburn (from 493.6 to 483.4), nausea (from 497.2 to 492.1), diarrhea (from 494.9 to 473.3), and constipation (from 487.8 to 467.7), with declines in QoL scores ranging from 4.6 to 34.0 points across symptom categories, indicating a significant impact on patients' quality of life.
conclusionGI symptoms significantly impair HRQoL in cancer patients undergoing chemotherapy, affecting physical functioning, emotional well-being, social interactions, energy levels, and overall health. A multidisciplinary approach, incorporating psychological support and social rehabilitation, is crucial for managing symptoms and enhancing patient well-being.
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