Evidence map›Paper›PMID 40167825›Full record

ArticleMetabolic brain disease2025

Ursolic acid derivatives improved clinical signs of experimental autoimmune encephalomyelitis by modulating central nervous system inflammation.

Elaine Carlos Scherrer, Karla Antunes Ramos, Ydia Mariele Valadares, Igor Gabriel Machado Soares, Alessandra Paula Carli, Fernando Sá Silva, Jeferson Gomes Silva, Daniel Gomes Alvarenga, Alessa Sin Singer Brugiolo, Rodrigo Moreira Verly and 4 more

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elaine Carlos ScherrerLife Sciences Institute, Federal University of Juiz de Fora, Governador Valadares, MG, Brazil.
Karla Antunes RamosFaculty of Medicine, Federal University of the Valleys of Jequitinhonha and Mucuri, MG, Teófilo Otoni, Brazil.
Ydia Mariele ValadaresLife Sciences Institute, Federal University of Juiz de Fora, Governador Valadares, MG, Brazil.
Igor Gabriel Machado SoaresFaculty of Medicine, Federal University of the Valleys of Jequitinhonha and Mucuri, MG, Teófilo Otoni, Brazil.
Alessandra Paula CarliFaculty of Medicine, Federal University of the Valleys of Jequitinhonha and Mucuri, MG, Teófilo Otoni, Brazil.
Fernando Sá SilvaLife Sciences Institute, Federal University of Juiz de Fora, Governador Valadares, MG, Brazil.
Jeferson Gomes SilvaLife Sciences Institute, Federal University of Juiz de Fora, Governador Valadares, MG, Brazil.
Daniel Gomes AlvarengaLife Sciences Institute, Federal University of Juiz de Fora, Governador Valadares, MG, Brazil.
Alessa Sin Singer BrugioloLife Sciences Institute, Federal University of Juiz de Fora, Governador Valadares, MG, Brazil.
Rodrigo Moreira VerlyDepartment of Chemistry, Federal University of the Valleys of Jequitinhonha and Mucuri, Diamantina, MG, Brazil.
Maiara Rodrigues SalvadorLife Sciences Institute, Federal University of Juiz de Fora, Governador Valadares, MG, Brazil.
Angelo Marcio Leite DenadaiLife Sciences Institute, Federal University of Juiz de Fora, Governador Valadares, MG, Brazil.
Caio César Souza AlvesFaculty of Medicine, Federal University of the Valleys of Jequitinhonha and Mucuri, MG, Teófilo Otoni, Brazil. caio.alves@ufvjm.edu.br.ORCID 0000-0001-9765-8527
Sandra Bertelli Ribeiro CastroFaculty of Medicine, Federal University of the Valleys of Jequitinhonha and Mucuri, MG, Teófilo Otoni, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immunopathogenesis of multiple sclerosis (MS) involves the activation of T lymphocytes, leading to progressive axonal loss and brain atrophy. Ursolic acid (AU) has been widely used as an herbal medicine, with the ability to inhibit the production and secretion of cytokines and may influence the differentiation of CD4 + helper cells. In this study, we aimed to investigate the immunomodulatory effects of ursolic acid derivatives (methyl 3β-hydroxyurs-12-en-28-oate (AUD1) and methyl 3β-acetoxyurs-12-en-28-oate (AUD2)) in a model of experimental autoimmune encephalomyelitis (EAE). EAE was induced by subcutaneous immunization of myelin oligodendrocyte glycoprotein peptide (MOG

Indexed as

Central Nervous SystemEncephalomyelitis, Autoimmune, ExperimentalTriterpenesAnimalsBrainCytokinesFemaleMiceMice, Inbred C57BLMyelin-Oligodendrocyte GlycoproteinNeuroinflammatory DiseasesSpinal CordUrsolic AcidCytokinesMyelin-Oligodendrocyte GlycoproteinTriterpenesUrsolic AcidAntigen-presenting cellDemyelinationMultiple sclerosisTreg cellsTriterpene

Identifiers

PMID40167825

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.