SynthesisLasers in medical science2025
Systematic review and meta-analysis - microfocused ultrasound treatment for sagging skin.
Synthesis in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Observational
- Advances in Anti-aging Procedures: A Comprehensive Review of Surgical and Non-surgical Rejuvenation Techniques.Cureus · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-Intensity Microfocused Ultrasound (HIFU) applies the high energy of focused ultrasound (US) to penetrate deeply into skin tissue. Despite significant investments in this technology and positive reports from clinical practitioners, scientific discussions reveal substantial controversy regarding its effects. This study aimed to perform a systematic review with meta-analysis to evaluate the evidence on HIFU's effectiveness in improving skin sagging across short, medium, and long-term outcomes, along with its potential adverse effects. A systematic search was conducted across PubMed, Medline, Embase, CINAHL, and the Cochrane Central Library. Out of One hundred and eighteen articles identified after duplicate removal, 99 studies underwent eligibility evaluation, resulting in the selection of 12 articles, including three randomized and nine non-randomized studies. Two randomized studies qualified for inclusion in the meta-analysis. The review indicates that high-intensity microfocused ultrasound shows promising results in improving skin sagging, with a total of 475 participants evaluated (333 women and 142 men). The meta-analysis of two studies on neck skin sagging improvement showed no significant difference between HIFU and RF groups across short-, medium-, and long-term outcomes (CI: 0.19 [-0.84, 0.45]; -0.5 [-0.65, 0.55]; -0.45 [-0.99, 0.09]). Although HIFU therapy appears beneficial for skin sagging, further high-quality, standardized studies are required to confirm these findings and reduce methodological biases.
Indexed as
Identifiers
40167815What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.