Evidence map›Paper›PMID 40167814›Full record

ArticleEuropean journal of nutrition2025

Associations of moderate alcohol intake with cerebrospinal fluid biomarkers of Alzheimer's disease: data from the ALBION study.

Archontoula Drouka, Klairi-Despoina Ntetsika, Dora Brikou, Eirini Mamalaki, Eva Ntanasi, Stylianos Chatzipanagiotou, Yian Gu, Nikolaos Scarmeas, Mary Yannakoulia

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Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
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  9. Cerebral amyloid angiopathy: a narrative review.Frontiers in aging neuroscience · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Archontoula DroukaDepartment of Nutrition and Dietetics, Harokopio University, Athens, 17671, Greece.
Klairi-Despoina NtetsikaDepartment of Nutrition and Dietetics, Harokopio University, Athens, 17671, Greece.
Dora BrikouDepartment of Nutrition and Dietetics, Harokopio University, Athens, 17671, Greece.
Eirini MamalakiDepartment of Nutrition and Dietetics, Harokopio University, Athens, 17671, Greece.
Eva NtanasiDepartment of Nutrition and Dietetics, Harokopio University, Athens, 17671, Greece.
Stylianos ChatzipanagiotouDepartment of Medical Biopathology and Clinical Microbiology, Aiginition Hospital, Athens Medical School, National and Kapodistrian University, Athens, 11528, Greece.
Yian GuThe Gertrude H. Sergievsky Center, Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, 10032, USA.
Nikolaos ScarmeasDepartment of Neurology, Medical School, Aiginition Hospital, National and Kapodistrian University of Athens, Athens, 11528, Greece.
Mary YannakouliaDepartment of Nutrition and Dietetics, Harokopio University, Athens, 17671, Greece. myiannak@hua.gr.ORCID http://orcid.org/0000-0003-2171-7337

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAccording to a WHO statement, it has been asserted that there is no safe level of alcohol consumption regarding human health. Nevertheless, the relationship between alcohol consumption and Alzheimer's disease (AD) pathology remains unclear. Therefore, we examined whether the frequency and patterns of alcohol consumption could predict neurodegeneration biomarkers in a cohort of middle-aged adults without dementia.

methodsA total of 195 participants without dementia were included from the ALBION study. Multivariate logistic regression analyses were conducted using drinking frequency subgroups (abstainers, occasional drinkers, and light-to-moderate drinkers) and Mediterranean-Alcohol Dietary Pattern (MADP) adherence subgroups along with cerebrospinal fluid (CSF) AD biomarkers (Tau, phosphorylated tau (PTau) and amyloid beta (Aβ). In these analyses, the abstinence was used as the reference category.

resultsOf the 195 individuals without dementia, 66% were female, with an average age of 65 ± 9.4 years, and they had 13.8 ± 3.6 years of education. Logistic regression analyses revealed that light-to-moderate drinkers (n = 51) were associated with higher Aβ positivity [OR: 2.98 (1.29-6.90)] compared to the abstinence (n = 117). Additionally, high adherence to the MADP was significantly associated with higher Aβ, Tau/Aβ

conclusionLight-to-moderate alcohol intake was associated with higher Aβ deposition in middle-aged individuals without dementia, compared to abstinence. High adherence to the MADP, which indicates low-to-moderate red wine consumption distributing over the week with meals, was associated with a higher Aβ and Tau/Aβ and PTau/Aβ positivity. Therefore, the management of alcohol consumption may help improve AD outcomes even at the preclinical stage.

Indexed as

Alcohol DrinkingAlzheimer DiseaseAmyloid beta-PeptidesAgedBiomarkersCohort StudiesDiet, MediterraneanFemaleHumansMaleMiddle Agedtau ProteinsAmyloid beta-PeptidesBiomarkerstau ProteinsAlcohol consumptionAlzheimer’s diseaseAmyloid betaCerebrospinal fluidMediterranean-alcohol dietary patternNeurodegeneration biomarkers

Identifiers

PMID40167814
PMCPMC11961535

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