ArticleJournal of neurology2025
Neurological disability and brain grey matter atrophy in primary progressive multiple sclerosis are determined by microstructural lesional changes, but not by lesion load.
Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConventional MRI measures, such as the number and volume of MS lesions, are histologically non-specific and cannot sufficiently explain clinical disability or brain atrophy in MS. Nevertheless, demyelinating plaques exhibit distinct histopathological features in relapsing and progressive multiple sclerosis (MS) subtypes. The aim of this study was to assess microstructural characteristics of MS lesions using quantitative MRI and explore their associations with grey matter (GM) atrophy and clinical disability.
methods56 control subjects (CS), 121 patients with relapsing-remitting (RRMS), and 38 patients with primary progressive MS (PPMS) underwent 1.5 T MRI scans and clinical examinations. Lesion and brain segmentation based on T1-weighted and FLAIR images were performed using SAMSEG. The MDME sequence and SyMRI software were used to estimate relaxation rates and myelin volume fraction in MS lesions and normal-appearing white matter (NAWM). Associations between quantitative lesional and NAWM MRI parameters with GM atrophy and clinical disability were investigated.
resultsBrain regional volumes and quantitative lesional and NAWM MRI parameters were significantly decreased in patients with PPMS compared to those with RRMS. Quantitative lesional MRI parameters demonstrated statistically significant associations with cortical and deep GM volumes as well as with disability scores in RRMS and especially in PPMS. In contrast to RRMS, lesion volume was not associated with either GM atrophy or clinical disability in the PPMS group.
conclusionsQuantitative lesional MRI measures, but not lesion load, were strongly associated with clinical disability and GM atrophy in PPMS patients, likely reflecting differences in lesion pathology between MS subtypes.
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