ArticleThe journal of spinal cord medicine2025
Spinal cord injury and male infertility: Effect of the inflammasome proteins on semen quality.
Article in The journal of spinal cord medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate seminal plasma levels of Biglycan, Cystatin-S, β-2 microglobulin and inflammasome proteins and to investigate their role in seminal toxicity in men with spinal cord injury (SCI). STUDY
designcross-sectional study.
settingMiami Project to Cure Paralysis - University of Miami / Miller School of Medicine and Federal University of Sao Paulo.
participantsEight men with spinal cord injury and eight men without spinal cord injury (controls).
interventionnone. Outcome measures: semen analysis as per WHO 2010 guidelines; seminal plasma ELISA for IL-1β, IL-18 and caspase-1; and Western blotting for Biglycan, β-2microglobulin and Cystatin-S proteins.
resultsProteins from the inflammasome complex are elevated in men with SCI, as previously described. In addition, β-2-microgobulin, Cystatin-S and two different isoforms of Byglican are elevated in men with SCI.
conclusiona different pathway to activate the inflammasome complex is present in men with spinal cord injury. This pathway can be a potential target for new interventions in the future.
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