Evidence map›Paper›PMID 40167640›Full record

ArticleExperimental brain research2025

Relating cortical morphology, corticospinal excitability, corticomotor representation, and quadriceps strength after anterior cruciate ligament injury.

Maria C Canino, Nicholas Arvin, Zechariah Nachazel, James J Irrgang, Adam Popchak, Volker Musahl, Adam J Sterczala, Shawn D Flanagan

Abstract read
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria C CaninoDepartment of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA. maria.canino.ctr@usuhs.edu.ORCID http://orcid.org/0000-0001-5114-4483
Nicholas ArvinDepartment of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA.
Zechariah NachazelDepartment of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA.
James J IrrgangDepartment of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-7529-2672
Adam PopchakDepartment of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-4932-6541
Volker MusahlDepartment of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Adam J SterczalaDepartment of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-0322-6836
Shawn D FlanaganDepartment of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-6531-4567

Funding

CMU-Pitt BRIDGE Center CMU-Pitt BRIDGE CenterDepartment of Sports Medicine and Nutrition, University of Pittsburgh Department of Sports Medicine and Nutrition, University of PittsburghSchool of Health and Rehabilitation Sciences, University of Pittsburgh School of Health and Rehabilitation Sciences, University of Pittsburgh
6 · The paper itself

Abstract

The current study investigated the relationship between sensorimotor cortical thickness, corticospinal excitability, corticomotor topography, and quadriceps strength after ACL reconstruction (ACLR). Ten women with a history of unilateral ACLR and 10 controls (CON) received single-pulse transcranial magnetic stimulation during unilateral, submaximal isometric knee extensions. Pulses were delivered to each vastus medialis oblique (VMO) hotspot with concurrent biceps femoris (BF) monitoring. Corticospinal excitability was assessed by delivering 40 pulses at various intensities to each hotspot. Motor-evoked potentials (MEPs) were averaged at each intensity and fitted to a Boltzmann sigmoidal curve using nonlinear regression to derive v50, slope, and MEP

Indexed as

Anterior Cruciate Ligament InjuriesEvoked Potentials, MotorMotor CortexMuscle StrengthPyramidal TractsQuadriceps MuscleAdultAnterior Cruciate Ligament ReconstructionElectromyographyFemaleHumansMagnetic Resonance ImagingTranscranial Magnetic StimulationYoung AdultCorticomotor functionLower extremitiesNeuroplasticityTranscranial magnetic stimulationTraumatic ligamentous injury

Identifiers

PMID40167640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.