ArticleBehavioural pharmacology2025
Theobromine synergizes with nicotine to enhance animal motor abilities and cognitive function.
Article in Behavioural pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The societal consensus on the need for smoking cessation is well-established, yet the number of tobacco users continues to rise. This trend is largely driven by the potent physiological effects of nicotine, which significantly increase the likelihood of tobacco use initiation. Certain compounds found in everyday foods, such as theobromine and caffeine in cocoa products, also exhibit psychostimulatory properties. However, comprehensive studies on the effects of consuming these compounds in the context of tobacco use are limited. This study investigates the role of theobromine, a primary active component in cocoa, in modulating the positive physiological effects of nicotine and explores the underlying mechanisms. Our findings reveal that while low doses of theobromine do not alter nicotine's addictive properties, they amplify its positive physiological effects. Notably, theobromine's impact on nicotine varies significantly between the hippocampus and cerebellum, highlighting region-specific interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.