Evidence map›Paper›PMID 40167560›Full record

Trial reportHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2025

Relationship intervention moderates the association between substance use and biological aging among Black adults.

Danielle M Weber, Justin A Lavner, Sierra Carter, Mei-Ling Ong, Man-Kit Lei, Robert Philibert, Steven R H Beach

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Danielle M WeberDepartment of Psychology, University of Georgia.ORCID 0000-0002-6387-6128
Justin A LavnerDepartment of Psychology, University of Georgia.
Sierra CarterDepartment of Psychology, Georgia State University.
Mei-Ling OngCenter for Family Research, University of Georgia.
Man-Kit LeiCenter for Family Research, University of Georgia.
Robert PhilibertDepartment of Psychiatry, University of Iowa.
Steven R H BeachDepartment of Psychology, University of Georgia.

Funding

Research Support CoreP50DA051361 · NIDA · UNIVERSITY OF GEORGIA · PI EHRLICH, KATHERINE BABCOCK · 2020 to 2024
$9.7M
Using a Randomized Prevention Trial to Understand the Health Benefits of Supportive Couple Relationships among Rural African American AdultsR01AG059260 · NIA · UNIVERSITY OF GEORGIA · PI BEACH, STEVEN R · 2018 to 2022
$3.2M
Home-based Prevention for African American Families in Rural CommunitiesR01HD069439 · NICHD · UNIVERSITY OF GEORGIA · PI BEACH, STEVEN R · 2012 to 2016
$2.6M
National Institute of Child Health and Human DevelopmentNIA NIH HHSNIA NIH HHS R01 AG059260NICHD NIH HHS R01 HD069439NIDA NIH HHSNIDA NIH HHS P50 DA051361
6 · The paper itself

Abstract

objectiveBlack Americans face disproportionate challenges related to substance use and the health impacts of substance use, including accelerated aging. Accordingly, interventions are needed to protect against the harmful effects of substance use on accelerated aging. The present study examined whether the Protecting Strong African American Families (ProSAAF) intervention, a relationship education program designed to promote strong relationships among Black families, moderated the association between substance use and accelerated aging among Black couples.

methodBlack couples received either the ProSAAF intervention or a minimal-touch control intervention and provided deoxyribonucleic acid specimens for methylation-based biomarker measurements of alcohol use and cigarette smoking (Alcohol T scores and cg05575921, combined into a substance use composite) and accelerated aging (DNAm GrimAge) 6- and 9 years postintervention.

resultsParticipants receiving the ProSAAF intervention (relative to the control condition) experienced a significantly weaker association between substance use and accelerated aging. Among the participants who were in the same relationship as when they were initially randomized, the association between substance use and aging was significantly weaker in the ProSAAF condition than in the control condition for participants with lower relationship satisfaction preintervention; no differences emerged among those with higher satisfaction.

conclusionsProSAAF mitigated some of the harmful effects of substance use on accelerated aging among Black couples, particularly among those with lower preintervention relationship satisfaction. These findings highlight the potential for relationship interventions to serve as sources of constructed resilience that promote healthier aging. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Indexed as

AgingAlcohol DrinkingBlack or African AmericanInterpersonal RelationsSubstance-Related DisordersAdultAgedFemaleHumansMaleMiddle AgedWhite

Identifiers

PMID40167560
PMCPMC12353662

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.