Evidence map›Paper›PMID 40167441›Full record

ArticleeLife2025

UBR-1 deficiency leads to ivermectin resistance in

Yi Li, Long Gong, Jing Wu, Wesley Hung, Mei Zhen, Shangbang Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi Li *Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Long Gong *Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Jing Wu *Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Wesley HungLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada.
Mei ZhenLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada.ORCID https://orcid.org/0000-0003-0086-9622
Shangbang GaoKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0001-5431-4628

Funding

Major International Joint Research Programme 32020103007National Key Research and Development Program of China 2022YFA1206000National Natural Science Foundation of China 32371189
6 · The paper itself

Abstract

Resistance to anthelmintics, particularly the macrocyclic lactone ivermectin (IVM), presents a substantial global challenge for parasite control. We found that the functional loss of an evolutionarily conserved E3 ubiquitin ligase, UBR-1, leads to IVM resistance in

Indexed as

AnthelminticsCaenorhabditis elegansCaenorhabditis elegans ProteinsDrug ResistanceIvermectinUbiquitin-Protein LigasesAnimalsChloride ChannelsGlutamic AcidAnthelminticsCaenorhabditis elegans ProteinsChloride Channelsglutamate-gated chloride channelsGlutamic AcidIvermectinUbiquitin-Protein LigasesAnthelmintic resistanceCeftriaxoneC. elegansgeneticsgenomicsGluClsglutamate metabolismIvermectinUBR-1 deficiency

Identifiers

PMID40167441
PMCPMC11961118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.