ArticleJournal of cosmetic dermatology2025
Treatment of Porphyria Cutanea Tarda Scarring With Combination Laser Treatment and a Pilot Use of Artificial Intelligence to Quantify Laser Results.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPorphyria cutanea tarda (PCT) is the most common subtype of porphyria and results from a deficiency of the enzyme uroporphyrinogen decarboxylase. Even after successful treatment, patients can be left with significant scarring, and there is little published data on the safety and efficacy of light-based or laser-based therapies.
methodsThis report examines a case of a 47-year-old male with PCT secondary to HCV, treated with a combination of fractionated erbium-doped yttrium-aluminum-garnet (Er:YAG), intense pulsed light (IPL), and carbon dioxide (CO
resultsAfter combination laser treatment, the patient exhibited marked improvements in skin texture, reduction in scar visibility, and diminished hyperpigmentation. The artificial intelligence algorithm quantified the laser results and showed improvements in the scores used in the large language model.
conclusionIn this patient, customizing a combination of lasers to target different layers of the skin to achieve comprehensive improvement: erbium primarily addressed superficial irregularities and pigmentation, while CO
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