Evidence map›Paper›PMID 40167320›Full record

ArticleJournal of the American Chemical Society2025

Nature of the Reactive Biferric Peroxy Intermediate P' in the Arylamine Oxygenases and Related Binuclear Fe Enzymes.

Lars H Böttger, Dory E DeWeese, Shyam R Iyer, Anna J Komor, Melanie S Rogers, Kyle Sutherlin, Ari B Jacobs, Yoshitaka Yoda, Shinji Kitao, Yasuhiro Kobayashi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Heme oxygenase-like dimetal oxidases and oxygenases.Biochemical Society transactions · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lars H BöttgerDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0003-3436-3451
Dory E DeWeeseDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Shyam R IyerDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Anna J KomorDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Melanie S RogersCenter for Metals in Biocatalysis, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-2657-7065
Kyle SutherlinDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Ari B JacobsDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Yoshitaka YodaJapan Synchrotron Radiation Research Institute, Hyogo 679-5198, Japan.
Shinji KitaoInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Osaka 590-0494, Japan.
Yasuhiro KobayashiInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Osaka 590-0494, Japan.
Jiyong ZhaoArgonne National Laboratory, Lemont, Illinois 60439, United States.
Esen Ercan AlpArgonne National Laboratory, Lemont, Illinois 60439, United States.
Makina SaitoResearch Reactor Institute, Kyoto University, Osaka 590-0494, Japan.
Makoto SetoInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Osaka 590-0494, Japan.
Lawrence QueDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-0989-2813
John D LipscombCenter for Metals in Biocatalysis, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-8158-5594
Edward I SolomonDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0003-0291-3199

Funding

Intermediates in O2 Activation by Oxygenases at Non-heme Iron CentersR35GM118030 · NIGMS · UNIVERSITY OF MINNESOTA · PI LIPSCOMB, JOHN D · 2016 to 2020
$2.7M
Spectroscopic Characterization of Oxygen Intermediates in Non-heme and Heme Iron EnzymesR35GM145202 · NIGMS · STANFORD UNIVERSITY · PI EDWARD I SOLOMON · 2022 to 2026
$2.0M
Roles of protein structure and diiron cluster chemistry in oxygen activationR01GM100943 · NIGMS · UNIVERSITY OF MINNESOTA · PI LIPSCOMB, JOHN D · 2012 to 2015
$1.2M
NIGMS NIH HHS R01 GM100943NIGMS NIH HHS R35 GM118030NIGMS NIH HHS R35 GM145202
6 · The paper itself

Abstract

Binuclear nonheme iron enzymes activate O

Indexed as

OxygenasesDensity Functional TheoryModels, MolecularOxidation-ReductionOxygenOxygenOxygenases

Identifiers

PMID40167320
PMCPMC12057066

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.