Evidence map›Paper›PMID 40167280›Full record

ArticleActa obstetricia et gynecologica Scandinavica2025

Mediators affecting the higher risk of stillbirth among foreign-born women in Sweden: A nationwide cohort study.

Minna Lundén, Ingela Hulthén Varli, Helena Kopp Kallner, Hanna Åmark

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Article in Acta obstetricia et gynecologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Minna LundénDepartment of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden.ORCID 0009-0005-6380-1133
Ingela Hulthén VarliDepartment of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Helena Kopp KallnerDepartment of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0001-7184-9165
Hanna ÅmarkDepartment of Clinical Science and Education, Unit of Obstetrics and Gynecology, Södersjukhuset, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0001-7599-567X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn Sweden, a higher incidence of stillbirth has been observed among women originating from sub-Saharan Africa and the Middle East. In this nationwide cohort of more than 2 million births, we assessed the risk factors for stillbirth among foreign-born women with the aim of understanding which mediators have the largest impact on the elevated risk of stillbirth. MATERIAL AND

methodsThis was a nationwide cohort study in Sweden including 2 300 391 births between 2000 and 2021. Data from the National Medical Birth Register were linked to data from Statistics Sweden using the personal identity number of the mother. Differences in maternal characteristics were analyzed between women divided into groups based on maternal country of origin. Logistic regression models were made with a forward selection strategy adjusting for potential mediators on the causal pathway from maternal country of origin to stillbirth.

resultsA significantly higher risk of stillbirth was observed among women originating from Eastern Europe, the Middle East/Northern Africa, sub-Saharan Africa, and Asia, with the highest risk observed in women originating from sub-Saharan Africa (OR 2.40, 95% CI 2.16-2.67, p-value <0.001). After adjusting for maternal risk factors, fetuses small for gestational age, and socioeconomic factors, women originating from sub-Saharan Africa still had a significantly higher risk of stillbirth (OR 1.28, 95% CI 1.14-1.44, p-value <0.001) compared to women originating from Sweden. The risk among the other groups of foreign-born women was, however, equal to the risk among women originating from Sweden. Mediation analysis showed that 31.2% of the effect of sub-Saharan origin on stillbirth was mediated through fetuses small for gestational age, 12.7% through educational level, and 16.9% through disposable income level.

conclusionsIn Sweden, women originating from sub-Saharan Africa face a significantly higher risk of stillbirth even after adjusting for known risk factors. The higher risk is partly mediated by giving birth to fetuses small for gestational age and socioeconomic factors, but it cannot be explained altogether. This disparity may stem from multifactorial causes, including how risk populations utilize health care during pregnancies. Further studies are needed to find preventive measures to decrease the disparity.

Indexed as

Emigrants and ImmigrantsStillbirthAdultAfrica South of the SaharaCohort StudiesFemaleHumansMiddle EastPregnancyRegistriesRisk FactorsSocioeconomic FactorsSwedenepidemiologyobstetricsstillbirthSweden

Identifiers

PMID40167280
PMCPMC12087519

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