Evidence map›Paper›PMID 40167159›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Origins, Dispersal, and Impact: Bidirectional Introgression Between Chinese and European Pig Populations.

Yibin Qiu, Langqing Liu, Min Huang, Donglin Ruan, Rongrong Ding, Zebin Zhang, Enqin Zheng, Shiyuan Wang, Shaoxiong Deng, Xianglun Meng and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yibin QiuState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Langqing LiuState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Min HuangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Donglin RuanState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Rongrong DingState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Zebin ZhangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Enqin ZhengState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Shiyuan WangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Shaoxiong DengState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Xianglun MengState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Xinyan ChengState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Jiaxin ShiState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Yingshan YangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Fuchen ZhouState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Sixiu HuangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Huaqiang YangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Zicong LiState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Gengyuan CaiState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Zhenfang WuState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Jie YangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China.ORCID https://orcid.org/0000-0002-7031-2160

Funding

key Technologies R&D Program of Guangdong Province 2022B0202090002Local Innovative and Research Teams Project of Guangdong Province 2019BT02N630National Key Research and Development Program of China 2023YFD1300201Natural Science Foundation of Guangdong Province 2024A1515010967Young Scholars "Qihang" Program SL2023A04J00485
6 · The paper itself

Abstract

Human mediated intra-continental exchange of genetic material among domesticated organisms has never been restricted to a single direction. The introduction of pig breeds between China and Europe aims to enhance economically important traits in local populations. However, the reciprocal introgression pattern, specifically the role of introgressed genes and structural variations (SVs), remains underexplored. A global collection of whole-genome resequencing data is utilized from 418 pigs to generate comprehensive dataset, including single-nucleotide polymorphisms (SNPs) as well as SVs. The analysis reveals incomplete linkage disequilibrium between SVs and adjacent SNPs, highlighting the limitations of conventional SNP-based analyses in capturing the genetic effects of SVs. By examining both population-level SNPs and SVs, bidirectional introgression between Chinese and European pig populations is characterized. It is identified 3558 bidirectional introgressed genomic segments and 30 SVs, with haplotypes at BMP2, which are associated with improved body size. The origin and allele frequency trajectory of the BMP2 segment are further validated using ancient genomes, suggesting that the body size-enhancing haplotype likely originated from ancient European populations and has since maintained a relatively high allele frequency. Overall, the results highlight the significant role of bidirectional introgression in shaping the genetic composition and phenotypic traits in modern pig breeds.

Indexed as

Genetic IntrogressionAnimalsBreedingChinaEuropeGene FrequencyHaplotypesLinkage DisequilibriumPolymorphism, Single NucleotideSwineancient genomebidirectional introgressionbody sizepigstructural variation

Identifiers

PMID40167159
PMCPMC12165087

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.