Evidence map›Paper›PMID 40167147›Full record

ArticleThe Journal of antimicrobial chemotherapy2025

Pandemic human-associated extended-spectrum β-lactamase-producing Escherichia coli lineages of ST38, ST131 and ST141 identified in Viennese dogs.

Pia Saria, Pavlos G Doulidis, Amélie Desvars-Larrive, Adrienn Gréta Tóth, Iwan A Burgener, Alexandro Rodríguez-Rojas, Olga Makarova

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of antimicrobial chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Pia SariaCentre for Food Science and Veterinary Public Health, Clinical Department for Farm Animals and Food Systems Science, University of Veterinary Medicine, Vienna, Austria.ORCID 0009-0005-3122-3367
Pavlos G DoulidisDivision for Small Animal Internal Medicine, Clinical Centre for Small Animals, Department for Small Animals and Horses, University of Veterinary Medicine, Vienna, Austria.
Amélie Desvars-LarriveCentre for Food Science and Veterinary Public Health, Clinical Department for Farm Animals and Food Systems Science, University of Veterinary Medicine, Vienna, Austria.
Adrienn Gréta TóthCentre for Bioinformatics, University of Veterinary Medicine, Budapest, Hungary.
Iwan A BurgenerDivision for Small Animal Internal Medicine, Clinical Centre for Small Animals, Department for Small Animals and Horses, University of Veterinary Medicine, Vienna, Austria.
Alexandro Rodríguez-RojasDivision for Small Animal Internal Medicine, Clinical Centre for Small Animals, Department for Small Animals and Horses, University of Veterinary Medicine, Vienna, Austria.
Olga MakarovaCentre for Food Science and Veterinary Public Health, Clinical Department for Farm Animals and Food Systems Science, University of Veterinary Medicine, Vienna, Austria.ORCID 0000-0003-4767-9711

Funding

European Union's Horizon 2020 874735FWF project 10.55776/P37311Hochschuljubiläumsfonds der Stadt Wien H-458732/2023
6 · The paper itself

Abstract

objectivesTo assess the prevalence of ESBL Enterobacteriaceae among dogs attending a veterinary clinic in Vienna, characterize the isolates in terms of antimicrobial resistance, virulence and phylogenetic relationships.

methodsFaecal samples of 88 dogs were streaked on selective plates, species were identified by MALDI-ToF MS, tested for resistance by a combination disk test and VITEK 2®, whole genome-sequenced, bioinformatically genotyped, phylogenetically analysed and screened for resistance and virulence genes.

resultsESBL Escherichia coli carriage rate was 14.8% (95% CI: [8.1-23.9]). No carbapenem resistance was found, but 53.8% of the isolates were classified genotypically as multi-drug resistant. Phylogenetic analyses revealed that half of the isolates belonged to animal and environment-associated phylogroups, while another half was human-associated, and included high-risk international clones of ST38, ST131 and ST141, which clustered primarily with human isolates. All isolates harboured various virulence-associated genes, including four isolates that encoded exotoxins, of which two were from the pandemic ST131 and emerging ST141 lineages.

conclusionsDogs in Vienna carry ESBL E. coli with high rates of multi-drug resistance and virulence, and a highly diverse population structure that includes pandemic human-associated lineages.

Indexed as

beta-LactamasesCarrier StateDog DiseasesEscherichia coliEscherichia coli InfectionsAnimalsAnti-Bacterial AgentsAustriaDogsDrug Resistance, Multiple, BacterialFecesGenotypeHumansMicrobial Sensitivity TestsPandemicsPhylogenyAnti-Bacterial Agentsbeta-LactamasesVirulence Factors

Identifiers

PMID40167147
PMCPMC12129576

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.