Evidence map›Paper›PMID 40166866›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025

Severe Cognitive Decline in Long-term Care Is Related to Gut Microbiome Production of Metabolites Involved in Neurotransmission, Immunomodulation, and Autophagy.

Andrew P Shoubridge, Lucy Carpenter, Erin Flynn, Lito E Papanicolas, Josephine Collins, David Gordon, David J Lynn, Craig Whitehead, Lex E X Leong, Monica Cations and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Andrew P ShoubridgeMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID 0000-0002-5148-4063
Lucy CarpenterMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Erin FlynnMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Lito E PapanicolasMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Josephine CollinsMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
David GordonSA Pathology, Adelaide, South Australia, Australia.ORCID 0000-0003-3276-9685
David J LynnInfection and Immunity, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.
Craig WhiteheadDepartment of Rehabilitation, Aged and Palliative Care, Flinders Medical Centre, Flinders University, Bedford Park, South Australia, Australia.
Lex E X LeongSA Pathology, Adelaide, South Australia, Australia.
Monica CationsRegistry of Senior Australians, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID 0000-0002-9262-0463
David P De SouzaBio21 Institute and Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia.
Vinod K NarayanaBio21 Institute and Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia.
Jocelyn M ChooMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Steve L WesselinghMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Maria CrottyDepartment of Rehabilitation, Aged and Palliative Care, Flinders Medical Centre, Flinders University, Bedford Park, South Australia, Australia.
Maria C InacioRegistry of Senior Australians, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID 0000-0001-8261-2665
Kerry IveyMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Steven L TaylorMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Geraint B RogersMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Funding

National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7M
Biomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2M
Australian Department of Health GNT1152268Australian Medical Research Future FundCommon Fund Data Ecosystem 3OT2OD030544EMBL Australia Group Leader AwardMatthew Flinders Professorial FellowshipMRFFNational Health and Medical Research Council GNT1155179NHMRC Emerging Leadership GNT2008625NHMRC Investigator Grant GNT119378NIDDK NIH HHS U2C DK119886NIH HHS OT2 OD030544NIH HHS U2C-DK119886The Hospital Research Foundation Mid-Career Fellowship MCF-27-2019
6 · The paper itself

Abstract

Aging-associated cognitive decline affects more than half of those in long-term residential aged care. Emerging evidence suggests that gut microbiome-host interactions influence the effects of modifiable risk factors. We investigated the relationship between gut microbiome characteristics and severity of cognitive impairment (CI) in 159 residents of long-term aged care. Severe CI was associated with a significantly increased abundance of proinflammatory bacterial species, including Methanobrevibacter smithii and Alistipes finegoldii, and decreased relative abundance of beneficial bacterial clades. Severe CI was associated with increased microbial capacity for methanogenesis, and reduced capacity for synthesis of short-chain fatty acids, neurotransmitters glutamate and gamma-aminobutyric acid, and amino acids required for neuroprotective lysosomal activity. These relationships were independent of age, sex, antibiotic exposure, and diet. Our findings implicate multiple gut microbiome-brain pathways in aging-associated cognitive decline, including inflammation, neurotransmission, and autophagy, and highlight the potential to predict and prevent cognitive decline through microbiome-targeted strategies.

Indexed as

AutophagyCognitive DysfunctionGastrointestinal MicrobiomeImmunomodulationSynaptic TransmissionAgedAged, 80 and overFemaleHomes for the AgedHumansMaleAged careCognitive impairmentMicrobiomeMicrobiome–gut–brain axis

Identifiers

PMID40166866
PMCPMC12168445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.