Evidence map›Paper›PMID 40166810›Full record

ArticleStroke2025

Association of Lp(a) With Stroke and Cerebral Injury on MRI: Insights From the HCHS/SOL (Hispanic Community Health Study/Study of Latinos) and Investigation of Neurocognitive Aging MRI (SOL-INCA MRI).

Akhil Avunoori Chandra, Priscilla Duran Luciano, Katrina Swett, Robert Kaplan, Gregory A Talavera, Melissa Lamar, Wassim Tarraf, Freddie Marquez, Parag H Joshi, Linda Gallo and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Akhil Avunoori Chandra *Department of Internal Medicine (A.A.C.), Montefiore Medical Center, Bronx, NY.ORCID 0000-0002-5460-0568
Priscilla Duran Luciano *Department of Medicine (P.D.L., K.S., C.J.R.), Albert Einstein College of Medicine, Bronx, NY.ORCID 0000-0003-4920-2941
Katrina SwettDepartment of Medicine (P.D.L., K.S., C.J.R.), Albert Einstein College of Medicine, Bronx, NY.
Robert KaplanDepartment of Epidemiology & Population Health (R.K., C.J.R.), Albert Einstein College of Medicine, Bronx, NY.ORCID 0000-0003-1571-4615
Gregory A TalaveraDepartment of Psychology, San Diego State University, Chula Vista, CA (G.A.T., L.G.).ORCID 0000-0001-5360-1107
Melissa LamarRush Alzheimer's Disease Center, Rush University, Chicago, IL (M.L.).ORCID 0000-0001-6130-5543
Wassim TarrafInstitute of Gerontology & Department of Healthcare Sciences, Wayne State University, Detroit, MI (W.T.).
Freddie MarquezDepartment of Neurosciences, University of California San Diego, La Jolla (F.M., H.G.).ORCID 0000-0001-9916-9225
Parag H JoshiDivision of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas (P.H.J.).ORCID 0000-0001-7863-2794
Linda GalloDepartment of Psychology, San Diego State University, Chula Vista, CA (G.A.T., L.G.).ORCID 0000-0002-3678-5888
Daniela Sotres-AlvarezDepartment of Biostatistics, University of North Carolina, Chapel Hill (D.S.-A.).ORCID 0000-0002-3226-6140
Morgan GianolaDepartment of Anesthesiology, University of California San Diego, La Jolla (M.G.).ORCID 0000-0002-6205-3015
Martha L DaviglusInstitute for Minority Health Research, University of Illinois College of Medicine at Chicago (M.L.D.).ORCID 0000-0002-6791-8727
Daniel L LabovitzDivision of Vascular Neurology (D.L.L.), Montefiore Medical Center, Bronx, NY.ORCID 0000-0003-0754-4345
Hector GonzalezDepartment of Neurosciences, University of California San Diego, La Jolla (F.M., H.G.).ORCID 0000-0003-4867-7902
Charles DeCarliDepartment of Neurology and Center for Neuroscience, University of California Davis Medical Center, Sacramento (C.D.).ORCID 0000-0003-1914-2693
Carlos J RodriguezDepartment of Medicine (P.D.L., K.S., C.J.R.), Albert Einstein College of Medicine, Bronx, NY.ORCID 0000-0003-0860-9008

Funding

Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Danielle Harvey · 2021 to 2026
$25.2M
Research Training and Education Core (Core D) P50HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2013 to 2017
$20.1M
MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of LatinosRF1AG054548 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2017 to 2017
$14.7M
Non-alcoholic Fatty Liver Disease and Cardiovascular Disease in Hispanics/LatinosR01HL144707 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI KIZER, JORGE R, LIMA, JOAO A C · 2019 to 2022
$9.3M
INTERGRATIVE CONTROL OF CARDIOVASCULAR FUNCTIONK02HL004199 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PAN, HUI-LIN · 2000 to 2003
$367k
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
CLC NIH HHS 75N90019D00011NHLBI NIH HHS 75N92021D00011NHLBI NIH HHS K02 HL004199NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS P50 HL120163NHLBI NIH HHS R01 HL144707NHLBI NIH HHS U01 HL146204NIA NIH HHS P30 AG072972NIA NIH HHS RF1 AG054548
6 · The paper itself

Abstract

backgroundLp(a) (lipoprotein[a]) is a risk factor for cardiovascular disease; however, its association with cerebrovascular disease is not as well established.

methodsData from a population-based cohort of Hispanics/Latinos included 16 333 individuals with baseline Lp(a) levels (nmol/L) and self-reported prevalent stroke or transient ischemic attack (TIA). A subset of 2642 individuals with brain magnetic resonance imaging was also included. Linear and multivariate logistic regression assessed the association of Lp(a) with (1) self-reported stroke or TIA, (2) cerebral injury defined as self-reported stroke or TIA or evidence of a stroke on brain magnetic resonance imaging, (3) white matter hyperintensity volume, and (4) silent brain infarcts. Sampling weights were utilized given the HCHS/SOL (Hispanic Community Health Study/Study of Latinos) complex sample design.

resultsMean age±SE was 41.1±0.3 years, 52.0% women, and median interquartile range (Q

conclusionsLp(a) is independently and significantly associated with prevalent stroke/TIA, and white matter hyperintensity, in a large diverse population of Hispanics/Latinos.

Indexed as

AgingIschemic Attack, TransientLipoprotein(a)StrokeAdultAgedBrainCohort StudiesFemaleHispanic or LatinoHumansMagnetic Resonance ImagingMaleMiddle AgedWhiteWhite MatterLipoprotein(a)cardiovascular diseasesHispanic or Latinolipoprotein(a)magnetic resonance imagingstroke

Identifiers

PMID40166810
PMCPMC12101938

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.